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microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis.

Neuro-oncology. 2019-01;

BhereDeepak，TamuraKaoru，WakimotoHiroaki，ChoiSung Hugh，PurowBenjamin，DebatisseJeremy，ShahKh

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Plasmid DNA Preparation	… Full-length EGFR 3′-UTR reporter plasmid was synthesized by GenScript Corp. using the entire EGFR 3′-UTR (nt 3879-5616 of GenBank™ accession number NM_005228) and the pMIR-REPORT luciferase plasmid backbone (Ambion) …	Get A Quote

摘要

MicroRNAs (miRs) are known to play a pivotal role in tumorigenesis， controlling cell proliferation and apoptosis. In this study， we investigated the potential of miR-7 to prime resistant tumor cells to apoptosis in glioblastoma (GBM).