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Predictive value of Borrelia burgdorferi IgG antibody levels in patients referred to a tertiary Lyme centre.

Ticks Tick Borne Dis. 2019-03; 
ZwerinkM,ZomerT P,van KootenB,BlaauwG,van BemmelT,van HeesB C,VermeerenY M,Landma
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Gene Synthesis … Isolate; **amino acids (aa); ***GenBank accession No. The sequences were optimized for their expression in E. coli using GeneOptimizer™ and synthesized respectively by GenScript corporation (Scotch Plains, NJ, USA) or GeneArt GmbH (Regensburg, Germany) … Get A Quote

摘要

A two-step testing strategy is recommended in serological testing for Lyme borreliosis; positive and indeterminate enzyme-linked immunosorbent assay (ELISA) results are confirmed with immunoblots. Several ELISAs quantify the concentration of antibodies tested, however, no recommendation exists for an upper cut-off value at which an IgG ELISA is sufficient and the immunoblot can be omitted. The study objective was to determine at which IgG antibody level an immunoblot does not have any additional predictive value compared to ELISA results. Data of adult patients who visited a tertiary Lyme centre between 2008 and 2014 were analysed. Both an ELISA (Enzygnost Lyme link VlsE IgG) and immunoblot (recomLine blot ... More

关键词

ELISA,Immunoblot,Lyme borreliosis,Positive predictive value,Sero