Exogenous cytokines， such as platelet-derived growth factor (PDGF)-B， can augment wound healing， but sustained delivery to maintain therapeutic levels remains a problem. "Genome editing" is a new technology in which precise genome modifications are made within cells using engineered site-specific nucleases. Genome editing avoids many of the complications associated with traditional gene therapy and the use of viral vectors， including random integration， imprecise gene expression， and inadvertent oncogene activation.
Exogenous cytokines， such as platelet-derived growth factor (PDGF)-B， can augment wound healing， but sustained delivery to maintain therapeutic levels remains a problem. "Genome editing" is a new technology in which precise genome modifications are made within cells using engineered site-specific nucleases. Genome editing avoids many of the complications associated with traditional gene therapy and the use of viral vectors， including random integration， imprecise gene expression， and inadvertent oncogene activation.
