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In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases.

J Neuroinflammation. 2010;

Bonneh-BarkayDafna，WangGuoji，StarkeyAdam，HamiltonRonald L，WileyClayt

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Custom Vector Construction	… containing the T7 promoter were generated by PCR from the pUC57 vector (GenScript, Piscataway, NJ) containing the full length YKL40 cDNA (NCBI Reference Sequence: NM_001276.2). 35 S-labeled RNA probes were generated using MAXIscript in vitro transcription kit …	Get A Quote

摘要

CHI3L1 (YKL-40) is up-regulated in a variety of inflammatory conditions and cancers. We have previously reported elevated CHI3L1 concentration in the cerebrospinal fluid (CSF) of human and non-human primates with lentiviral encephalitis and using immunohistochemistry showed that CHI3L1 was associated with astrocytes.