至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Metastatic Colorectal Cancer Rewrites Metabolic Program Through a Glut3-YAP-dependent Signaling Circuit.

Theranostics. 2019; 
KuoChih-Chia,LingHsiang-Hsi,ChiangMing-Chen,ChungChu-Hung,LeeWen-Ying,ChuCheng-Ying,WuYu-Chih,ChenCheng-Hsun,LaiYi-Wen,TsaiI-Lin,ChengChia-Hsiung,LinCheng
Products/Services Used Details Operation
Custom Vector Construction Full-length human Glut3 in the pcDNA4/DYK vector was purchased from GenScript. Get A Quote

摘要

: Cancer cells reprogram cellular metabolism to fulfill their needs for rapid growth and metastasis. However, the mechanism controlling this reprogramming is poorly understood. We searched for upregulated signaling in metastatic colorectal cancer and investigated the mechanism by which Glut3 promotes tumor metastasis. : We compared RNA levels and glycolytic capacity in primary and metastatic colon cancer. The expression and association of Glut3 with clinical prognosis in colon cancer tissues was determined by immunohistochemistry. Glut3 gain-of-function and loss-of-function were established using colon cancer HCT116, HT29, and metastatic 116-LM cells, and tumor invasiveness and stemness properties were ... More

关键词

YAP,cancer metabolism,colorectal cancer,glucose transporter,metast