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Alcohol Effects on Colon Epithelium are Time-Dependent.

Alcohol. Clin. Exp. Res.. 2019;

BishehsariFaraz，ZhangLijuan，VoigtRobin M，MaltbyNatalie，SemsariehBita，ZorubEyas，ShaikhMaliha，WilberSherry，ArmstrongAndrew R，MirbagheriSeyed Sina，PreiteNailliw Z，SongPeter，StornettaAlessia，BalboSilvia，ForsythChristopher B，Keshavarzia

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Plasmid DNA Preparation	… To knock out XPA, first the lentiviral transfer plasmid GenCRISPR gRNA Human-XPA crRNA6 pLentiCRISPR v2 (Human-XPA crRNA6) encoding human XPA was purchased from GenScript. psPAX2 is a 2nd generation lentiviral packaging vector and contains Gag …	Get A Quote

摘要

Alcohol intake increases the risk of developing colon cancer. Circadian disruption promotes alcohol's effect on colon carcinogenesis through unknown mechanisms. Alcohol's metabolites induce DNA damage， an early step in carcinogenesis. We assessed the effect of time of alcohol consumption on markers of tissue damage in the colonic epithelium.