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Potential Application of TALENs against Murine Cytomegalovirus Latent Infections.

Viruses. 2019; 
ChenShiu-Jau,ChenYuan-C
Products/Services Used Details Operation
Gene Synthesis … TaqMan probes (5′-TTCTCTGTCAGCTAGCCAATGATATCTTCGAGC-3′) were synthesized by Genscript, Nanjing, Jiangsu, China. The probe was labeled at the 5′ end with the reporter dye FAM and at the 3′ end with the quencher dye TAMRA. 2.5 … Get A Quote

摘要

Cytomegalovirus (CMV) infections are still a global health problem, because the latent viruses persist in humans and cause recurring disease. Currently, there are no therapies for CMV latent infections and the therapies for active infections are limited by side effects and other problems. It is impossible to eradicate latent viruses in animals. HCMV (human CMV) is specific to human diseases; however, it is difficult to study HCMV due to its host specificity and long life cycle. Fortunately, MCMV (murine CMV) provides an excellent animal model. Here, three specific pairs of transcription activator-like effector nuclease (TALEN) plasmids (MCMV1-2, 3-4, and 5-6) were constructed to target the MCMV M8... More

关键词

Surveyor nuclease mutation detection assay,TALEN,cytomegalovirus,ie-1 gene,latent infection,quantitative real-time