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Pectasol-C Modified Citrus Pectin targets Galectin-3-induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids.

Cancer Med. 2019; 
HosseinGhamartaj,HalvaeiSina,HeidarianYassaman,Dehghani-GhobadiZeinab,HassaniMina,HosseiniHoma,NaderiNima,Sheikh HassaniShah
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Molecular Biology Reagents … GmbH, Germany). Cleaved caspase‐3 col- orimetric assay kit was purchased from GenScript (NJ, USA); Pectasol‐C Modified Citrus Pectin (Pect‐MCP) was obtained from EcoNugenics (Santa Rosa, CA, USA). Recombinant … Get A Quote

摘要

Here we sought to determine the relationship between STAT3 activity and Galectin-3 (Gal-3) and to investigate the cytotoxic effect of PectaSol-C Modified Citrus Pectin (Pect-MCP) as a specific competitive inhibitor of Galectin-3 (Gal-3) in combination with Paclitaxel (PTX) to kill the ovarian cancer cell SKOV-3 multicellular tumor spheroid (MCTS). To this order, SKOV-3 cells in 2D and 3D cultures were treated with exogenous Gal-3 for the assessment of STAT3 activity. Two-way ANOVA main effect and IC of each drug Paclitaxel (PTX) and Pect-MCP or in combination were obtained from MTT assay results. The phosphorylated STAT3 levels, migration, invasion, integrin mRNA and p-AKTser levels were assessed in the... More

关键词

Galectin-3,STAT3,integrin,invasion,migration,ovarian ca