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Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques.

Virol. J.. 2016; 
PaharBapi,Kenway-LynchCarys S,MarxPreston,SrivastavSudesh K,LaBrancheCelia,MontefioriDavid C,DasAr
Products/Services Used Details Operation
Peptide Synthesis Five to 12-aa peptides from a 15mer SIV-Env peptide (sequence: KTVLPVTIMSGLVFH in V3 region) were synthesized commercially (GenScript, USA) and used as coating antigen at the concentration of 5 μg/ml to determine the exact length of a linear B-cell epitope. Get A Quote

摘要

Increasing evidence suggests an unexpected potential for non-neutralizing antibodies to prevent HIV infection. Consequently, identification of functional linear B-cell epitopes for HIV are important for developing preventative and therapeutic strategies. We therefore explored the role of antigen-specific immune responses in controlling plasma viremia in SIV infected rhesus macaques.

关键词

Antibody,Breadth,Correlate of protection,Neutralizing antibodies,Peptides,Rhesus macaque,SIV,SIV-anti