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Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.

Adv Healthc Mater. 2016; 
CaiLei,DewiRuby E,GoldstoneAndrew B,CohenJeffrey E,SteeleAmanda N,WooY Joseph,HeilshornSar
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Peptide Synthesis … P domain peptide (EYPPYPPPPYPSGC, 1563 g mol −1 ) was purchased through custom peptide synthesis from Genscript Corp (Piscataway, NJ). All other chemicals were purchased from Sigma‐Aldrich (Milwaukee, WI) unless otherwise noted … Get A Quote

摘要

A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.

关键词

angiogenic function,injectable hydrogels,molecular recognition,reinforcing network,stem cell secre