Chemical conjugation of therapeutic proteins with polyethylene glycol (PEG) is an established strategy to extend their biological half-life (t1/2 ) to a clinically useful range. We developed a novel uncharged and unstructured recombinant polypeptide composed of five amino acids (P， S， T， A and G)， named PsTag， as another approach to extend the t1/2 of human FGF21， with increased hydrodynamic radius.
Chemical conjugation of therapeutic proteins with polyethylene glycol (PEG) is an established strategy to extend their biological half-life (t1/2 ) to a clinically useful range. We developed a novel uncharged and unstructured recombinant polypeptide composed of five amino acids (P， S， T， A and G)， named PsTag， as another approach to extend the t1/2 of human FGF21， with increased hydrodynamic radius.
