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Inhaled PYY(3-36) dry-powder formulation for appetite suppression.

Drug Dev Ind Pharm. 2016-01;

KuehlPhilip J，BoydenTracey，DobryDan E，Doyle-EiseleMelanie，FriesenDwayne T，McDonaldJacob D，MurriBrice G，VodakDavid T，LyonDav

Products/Services Used	Details	Operation
Peptide Synthesis	… These data were used to select inhalation doses for pharmacodynamic assessment of inhalation PYY(3–36) in a mouse appetite suppression model. Materials and methods Materials PYY(3–36), amidated at the C-terminus, was purchased from GenScript USA Inc …	Get A Quote

摘要

Peptide YY3-36 [PYY(3-36)] has shown efficacy in appetite suppression when dosed by injection modalities (intraperitoneal (IP)/subcutaneous). Transitioning to needle-free delivery， towards inhalation， often utilizes systemic pharmacokinetics as a key endpoint to compare different delivery methods and doses. Systemic pharmacokinetics were evaluated for PYY3-36 when delivered by IP， subcutaneous， and inhalation， the systemic pharmacokinetics were then used to select doses in an appetite suppression pharmacodynamic study.