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Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses.

Antiviral Res.. 2015;

MohrEmma L，McMullanLaura K，LoMichael K，SpenglerJessica R，BergeronÉric，AlbariñoCésar G，Shrivastava-RanjanPunya，ChiangCheng-Feng，NicholStuart T，SpiropoulouChristina F，Flint

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摘要

Host cell kinases are important for the replication of a number of hemorrhagic fever viruses. We tested a panel of kinase inhibitors for their ability to block the replication of multiple hemorrhagic fever viruses. OSU-03012 inhibited the replication of Lassa， Ebola， Marburg and Nipah viruses， whereas BIBX 1382 dihydrochloride inhibited Lassa， Ebola and Marburg viruses. BIBX 1382 blocked both Lassa and Ebola virus glycoprotein-dependent cell entry. These compounds may be used as tools to understand conserved virus-host interactions， and implicate host cell kinases that may be targets for broad spectrum therapeutic intervention.