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Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation.

BMC Cancer. 2015-05;

ChoudharyMayur，NaczkiChristine，ChenWenhong，BarlowKeith D，CaseL Douglas，Metheny-BarlowLin

Products/Services Used	Details	Operation
Peptide Synthesis	… Co-cultures were also set up in the presence of 250 μM Cx43 GAP26 (sequence VCYDKSFPISHVR) or scrambled control peptide (GenScript, Piscataway, NJ); cultures received fresh media with GAP26 peptide on the third day of culture …	Get A Quote

摘要

Proper functional association between mural cells and endothelial cells (EC) causes EC of blood vessels to become quiescent. Mural cells on tumor vessels exhibit decreased attachment to EC， which allows vessels to be unstable and proliferative. The mechanisms by which tumors prevent proper association between mural cells and EC are not well understood. Since gap junctions (GJ) play an important role in cell-cell contact and communication， we investigated whether loss of GJ plays a role in tumor-induced mural cell dissociation.