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Is Saglin a mosquito salivary gland receptor for Plasmodium falciparum?

Malar. J.. 2019;

O'BrochtaDavid A，AlfordRobert，HarrellRobert，AluvihareChanna，EappenAbraham G，LiTao，ChakravartySumana，SimB Kim Lee，HoffmanStephen L，BillingsleyPet

Products/Services Used	Details	Operation
Gene Synthesis	… A 1541 bp fragment of DNA was synthesized consisting of 1239 bp (412 aa) of the Saglin open reading frame (nucleotides 1–1239; AY846632) and 302 bp containing the 3′ UTR of SV40 (GenScript Corporation, Piscataway, NJ) …	Get A Quote

摘要

Saglin， a 100 kDa protein composed of two 50 kDa homodimers， is present in the salivary glands of Anopheles gambiae and has been considered an essential receptor for sporozoites (SPZ) of Plasmodium berghei and Plasmodium falciparum (Pf)， allowing SPZ to recognize， bind to， and infect mosquito salivary glands. Spatial and temporal patterns of Saglin expression reported here， however， suggest that this model does not fully describe the Saglin-SPZ interaction.