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Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging

Cell. 2017;

Marjolein P. Baar, Renata M.C. Brandt, Diana A. Putavet, ..., Jan H.J. Hoeijmakers, Judith Campisi, Peter L.J. de Keizer

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摘要

Highlights d A modified FOXO4-p53 interfering peptide causes p53 nuclear exclusion in senescent cells d This FOXO4 peptide induces targeted apoptosis of senescent cells (TASC) d TASC neutralizes murine liver chemotoxicity from doxorubicin treatment d TASC restores fitness, hair density, and renal function in fast and naturally aged mice