| Products/Services Used | Details | Operation |
|---|---|---|
| Peptide Synthesis | Synthetic peptides, with over 90% purity, used for SrtA labelling, GGG-M2e (GGGSLLTEVETPIRNEWGCRCN DSSD) and GGG-T20 (GGGYTSLIHSLIEESQNQQ EKN EQELLELDKWASLWNWF) were purchased from GenScript (United States) and Biomatik (Canada), respectively. | Get A Quote |
Flexuous rod-shaped nanoparticles made of the coat protein (CP) of papaya mosaic virus (PapMV) have been shown to trigger innate immunity through engagement of toll-like receptor 7 (TLR7). PapMV nanoparticles can also serve as a vaccine platform as they can increase the immune response to fused peptide antigens. Although this approach shows great potential， fusion of antigens directly to the CP open reading frame (ORF) is challenging because the fused peptides can alter the structure of the CP and its capacity to self assemble into nanoparticles-a property essential for triggering an efficient immune response to the peptide. This represents a serious limitation to the utility of this approach as fusion of sma... More
