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Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium.

Matrix Biol.. 2017; 
GalvagniFederico,NardiFederica,SpigaOttavia,TrezzaAlfonso,TarticchioGiulia,PellicaniRosanna,AndreuzziEva,CaldiElena,TotiPaolo,TosiGian Marco,SantucciAnnalisa,IozzoRenato V,MongiatMaurizio,OrlandiniMaur
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Custom Vector Construction Theconstructsexpressingtheextracellulardomainsof CD93 fused to Myc and containing the mutations C141A, C165A, H236A, E242A, or D249A were purchased from GenScript (Piscataway, NJ, USA). Get A Quote

摘要

The glycoprotein CD93 has recently been recognized to play an important role in the regulation of the angiogenic process. Moreover, CD93 is highly expressed in the endothelial cells of tumor blood vessel and faintly expressed in the non-proliferating endothelium. Much evidence suggests that CD93 mediates adhesion in the endothelium. Here we identify Multimerin 2 (MMRN2), a pan-endothelial extracellular matrix protein, as a specific ligand for CD93. We found that CD93 and MMRN2 are co-expressed in the blood vessels of various human tumors. Moreover, disruption of the CD93-MMRN2 interaction reduced endothelial cell adhesion and migration, making the interaction of CD93 with MMRN2 an ideal target to bloc... More

关键词

Angiogenesis,C1qRp,EDEN protein superfamily,Endothelial