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IL-36α suppresses proliferation of ovarian cancer cells.

Tumour Biol.. 2017; 
ChangLei,GuoRuixia,YuanZho
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Custom Vector Construction For a vector-based RNAi approach, a double-stranded short hairpin RNA (shRNA) was cloned into the BamHI-Hind III sites of the pRNATU6.1/neo-cGFP vector (GenScript; Piscataway, NJ, USA). Get A Quote

摘要

Interleukin-36α (IL-36α), also formerly known as IL-1F6, is pertaining to IL-1 family members that has been shown to play an important pro-inflammatory role in chronic immune disorders. However, the role IL-36α in the setting of cancer remains unknown. Here, in our study, to investigate the clinical relevance of IL-36α in ovarian cancer, clinicopathological significance as well as expression level of IL-36α were analyzed in epithelial ovarian cancer clinical tissues and paired normal control. To explore the biological role of IL-36α in vitro in epithelial ovarian cancer cells, both overexpression and knockdown of IL-36α were performed. Based on the successful re-expression and silencing of ... More

关键词

Ovarian cancer,interleukin-36α,migration,prognosis,prolifera