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Generation and Characterization of a Functional Nanobody Against Inflammatory Chemokine CXCL10， as a Novel Strategy for the Treatment of Multiple Sclerosis.

CNS Neurol Disord Drug Targets. 2019-01; 
Sadeghian-RiziTahereh, BehdaniMahdi, KhanahmadHossein, SadeghiHamid Mirmohammad, Jahanian-Najafabad
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Stable Cell Line Development Services … Address correspondence to this author at the Department of Pharmaceuti- cal Biotechnology, Faculty of … of E. coli WK6 cells by osmotic shock and purified on Ni-NTA resins (GenScript) … mM imidazole were loaded on Super- dex 75 column (Pharmacia Biotech) and concentrated … Get A Quote

摘要

Chemokines and their receptors play a pivotal role in the pathogenesis of various autoimmune diseases such as multiple sclerosis， infectious diseases， and also in cancer metastasis via attraction of the pathogenic immune cells into the inflammation sites.

关键词

CXCL10，CXCR3，Chemotaxis，Heavy chain antibody，Multiple sclerosis，Nanob
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