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ACE-2/ANG1-7 ameliorates ER stress-induced apoptosis in seawater aspiration-induced acute lung injury.

Am. J. Physiol. Lung Cell Mol. Physiol.. 2018-10; 
ZhangMinLong,GaoYongheng,YuGaole,ZhaoWeiguo,JinFag
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Proteins, Expression, Isolation and Analysis … ELISA kits for ANGII and ANG1-7 were 126 obtained from R&D Systems (Minneapolis, MN, USA). MG132, ANG1-7 and A779 127 were purchased from GenScript (Piscataway, NJ, USA) … Get A Quote

摘要

Previous studies have shown that apoptosis of alveolar cells can be regulated by autocrine of ANGII and its counter regulatory ACE-2/ANG1-7 axis. Our earlier study has shown that ER stress in response to seawater aspiration eventually led to apoptosis in lung tissue. In this study, we examined the hypothesis that ER stress induced apoptosis in seawater aspiration-induced ALI might also be regulated by ANGII/ANG1-7 system. ER stress was induced by seawater stimulation and proteasome inhibitor MG132 (an ER stress inductor) . Moreover, ER stress in seawater stimulated lung tissues and RPMVECs promoted the ANGII expression and decreased ACE-2/ANG1-7 expression. ER stress induced by seawater stimulation also lea... More

关键词

ER stress,acute lung injury,angiotensin,apoptosis,seaw