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A Tick Cysteine Protease Inhibitor RHcyst-1 Exhibits Antitumor Potential.

Cell. Physiol. Biochem.. 2018;

WeiNana，LinZhibing，XuZhengmao，CaoJie，ZhouYongzhi，ZhangHoushuang，GongHaiyan，ZhouJinlin，LiGuo

Products/Services Used	Details	Operation
Proteins, Expression, Isolation and Analysis	… LPS was removed from the RHcyst-1 using Detoxi-Gel TM endotoxin-removing columns (Thermo Scientific TM , USA). Endotoxin levels were monitored using a Limulus amoebocyte lysate test (LAL, GenScript, China). The proteins were stored in PBS at -80 °C for later use …	Get A Quote

摘要

We previously identified a potent and tight-binding inhibitor of cysteine proteases from Rhipicephalus haemaphysaloides， RHcyst-1， which belongs to the cystatin type 1 family. Cathepsins， which are members of the cysteine protease family， participate in various pathological processes， including the initiation and development of cancers. The present study aimed to investigate the antitumor effects of RHcyst-1 and to explore the underlying mechanism of these effects.