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Loss-of-function mutations in caspase recruitment domain-containing protein 14 (CARD14) are associated with a severe variant of atopic dermatitis.

J. Allergy Clin. Immunol.. 2018-09; 
PeledAlon，SarigOfer，SunGuangping，SamuelovLiat，MaChi A，ZhangYuan，DimaggioTom，NelsonCeleste G，StoneKelly D，FreemanAlexandra F，MalkiLiron，VidalLucia Seminario，ChamarthyLatha M，BriskinValeria，MohamadJanan，PavlovskiMor，WalterJolan E，MilnerJoshua D，Spreche
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Mutagenesis Services … the manufacturer's protocol (Invitrogen). Mutations were introduced into the CARD14 sequence by using a mutagenesis service (Genscript, Piscataway, NJ) and validated by means of Sanger sequencing. As a positive control … Get A Quote

摘要

Atopic dermatitis (AD) is a highly prevalent chronic inflammatory skin disease that is known to be， at least in part， genetically determined. Mutations in caspase recruitment domain-containing protein 14 (CARD14) have been shown to result in various forms of psoriasis and related disorders.

关键词

Atopic dermatitis，CARD14，nuclear factor κB，psori
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