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Targeting CD6 for the treatment of experimental autoimmune uveitis.

J. Autoimmun.. 2018-06; 
ZhangLingjun，LiYan，QiuWen，BellBrent A，DvorinaNina，BaldwinWilliam M，SingerNora，KernTimothy，CaspiRachel R，FoxDavid A，Lin
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Peptide Synthesis … In brief, an aqueous solution containing 200 μg IRBP 161-180 peptide (SGIPYIISYLHPGNTILHVD; custom synthesized by GenScript USA Inc., Piscataway, NJ, USA) was emulsified with an equal volume of complete Freund's adjuvant (CFA; Difco Laboratories, Inc., Detroit, MI … Get A Quote

摘要

CD6 is emerging as a new target for treating many pathological conditions in which T cells are integrally involved， but even the latest data from studies of CD6 gene engineered mice were still contradictory. To address this issue， we studied experimental autoimmune uveitis (EAU)， a model of autoimmune uveitis， in wild-type (WT) and CD6 knockout (KO) mice.

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