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Oxabicycloheptene Sulfonate Protects Against β-Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells.

Neurochem Res.. 2017-08; 
Deng LJ,Cheng C,Wu J,Wang CH,Zhou HB,Huang J.
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Gene Synthesis ... real-time PCR with primers as following: GAPDH: 5′-GAT GGT GAA GGT CGG TGT GAA-3′ and 5′-CAA TGT CCA CTT TGT CAC AAG AGA A-3′. GPER1: 5′-TGG TGG TGA ACA TCA GCT TC-3′ and 5′-AAG CTC ATC CAG GTG AGG AA-3′ (Genscript Biotech, China). … Get A Quote

摘要

Oxabicycloheptene sulfonate (OBHS) is a novel bicyclic core selective estrogen receptor modulator (SERM) with estrogen receptor (ER) antagonistic-activity and anti-inflammatory activity. However, little is known about protective action of OBHS on neurodegenerative disorders. In the present study, OBHS demonstrated a remarkably protective effect against amyloid beta (Aβ) induced cytotoxicity via G-protein-coupled estrogen receptor 1 (GPER1) in rat astroglial cell line (C6). The C6 cell death induced by Aβ was decreased by OBHS (1 μM) treatment for 45 min. This rapid protective action was blocked by GPER1 specific antagonist or siRNA knockdown. Inhibitors of phosphatidylinositol 3-kinase (PI3k)/Akt and extra... More

关键词

Alzheimer’s disease; Amyloid beta; G-Protein-coupled estrogen receptor 1; Oxabicycloheptene sulfonate
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