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Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways.

Toxicol Appl Pharmacol.. 2016-01; 
Xu P, Zhang Y, Liu Y, Yuan Q, Song L, Liu M, Liu Z, Yang Y, Li J, Li D, Ren G.
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ToxinSensor Single Test Kit ... The FGF-21 was purified by a Ni Sepharose 6 Fast Flow column in AKTA Purifier (GE Healthcare). The endotoxin was removed from the purified FGF-21 by ToxinEraser™ Endotoxin Removal Kit (Nanjing Genscript Biotechnology Co., Ltd). ... Get A Quote

摘要

Fibroblast growth factor 21 (FGF-21) is a secreted protein, which has anti-diabetic and lipocaic effects, but its ability to protect against hepatic fibrosis has not been studied. In this study, we investigated the ability of FGF-21 to attenuate dimethylnitrosamine (DMN)-induced hepatic fibrogenesis in mice and the mechanism of its action. Hepatic fibrosis was induced by injection of DMN, FGF-21 was administered to the mice once daily in association with DMN injection till the end of the experiment. Histopathological examination, tissue 4-hydroxyproline content and expressions of smooth muscle α-actin (α-SMA) and collagen I were measured to assess hepatic fibrosis. Ethanol/PDGF-BB-activated hepatic stellate c... More

关键词

Fibroblast growth factor 21; Hepatic fibrogenesis; Hepatic stellate cells; NF-κB; TGF-β