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Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair

Authors: Xinye Chen, Yuanman Yu, Zirui He, Lina Pan, Jing Wang, Changsheng Liu

Journal: Advanced Science

Doi: 10.1002/advs.202504965

Products & Services: Peptide Synthesis

And then, proteins were resolved in 4–12% Bis-Tris SurePAGE gel (Genscript) and transferred to 0.45 µm PVDF membrane (Millipore) for blotting.

Authors: Sitao Zhang, Zixuan Jiang, Rundong Huang, Wenting Huang, Siyuan Peng, Shaoxun Mo, Letao Zhu, Peiheng Li, Ziyi Zhang, Emily Pan, Xi Chen, Yunfei Long, Qi Liang, Jin Tang, Renjing Xu, Rui Qing

Journal: Advanced Science

Doi: 10.1002/advs.202502723

Products & Services: Codon Optimization

NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence

Authors: Zheng Dai, Feng Liu, Miaodeng Liu, Yuqi Song, Hongyan Zhang, Cheng Zhou, Wenyu Liu, Xiaoqiong Li, Guobin Wang, Lin Wang, Zheng Wang

Journal: Bioactive Materials

Doi: https://doi.org/10.1016/j.bioactmat.2025.06.037

Products & Services: Catalog Peptides

Targeting Senescent Alveolar Type 2 Cells with a Gene-Editable FePt Dual-Atom Catalyst for Mitigating Idiopathic Pulmonary Fibrosis

Authors: Qianglan Lu, Chengwei Ye, Wei Mao, Fei Zeng, Zhiyong Liu, Ruiyue Chen, Xiao Cheng, Yanfeng Gao, Meng Wang, Mei Liu, Shaochun Tang, Yujun Song

Journal: ACS Nano .

PubMed ID: 40532220

Doi: 10.1021/acsnano.5c04686

Products & Services: CRISPR Libraries

Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination

Authors: Chuntong Li, Fangyu Zhao, Chong Zuo, Liying Zhang, Yangwode Jing, Xu Li, Guo-Chao Chu, Luyu Shi, Yingyue Zhang, Han Wang, Shuzhe Sun, Maoshen Sun, Huasong Ai, Lu-Jun Liang, Jinghong Li

Journal: Journal of the American Chemical Society

PubMed ID: 40561458

Doi: 10.1021/jacs.5c06399

Products & Services: Gene Synthesis Codon Optimization

Improving diffusion-based protein backbone generation with global-geometry-aware latent encoding

Authors: Yuyang Zhang, Yuhang Liu, Zinnia Ma, Min Li, Chunfu Xu & Haipeng Gong

Journal: Nature Machine Intelligence

Doi: doi.org/10.1038/s42256-025-01059-x

Products & Services: Gene Synthesis

The Design and Application of Inhibiting Peptide for Rapid In vitro Downregulation of Post-Translational Modifications Levels at a Specific Site

Authors: Shu-Ping Zhang, Jia-Qi Liu, Ning Su, Jie Yang, Zhi-Xia Yang, Dong Zhang, Xian-Zhe Gu

Journal: Journal of visualized experiments:JoVE

PubMed ID: 40622887

Doi: 10.3791/68581

Products & Services: Protein Electrophoresis and Western

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

Authors: Stephen A. Rettie; David Juergens; Victor Adebomi; Yensi Flores Bueso; Qinqin Zhao; Alexandria N. Leveille; Andi Liu; Asim K. Bera; Joana A. Wilms; Alina ffing; Alex Kang; Evans Brackenbrough; Mila Lamb; Stacey R. Gerben; Analisa Murray; Paul M. Levine; Maika Schneider; Vibha Vasireddy; Sergey Ovchinnikov; Oliver H. Weiergr ber; Dieter Willbold; Joshua A. Kritzer; Joseph D. Mougous; David Baker; Frank DiMaio; Gaurav Bhardwaj

Journal: Nature Chemical Biology

PubMed ID: 40542165

Doi: 10.1038/s41589-025-01929-w

Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis

Authors: Manuel L. Merz; Veronika M. Shoba; Rajaiah Pergu; Zachary C. Severance; Dhanushka N. P. Munkanatta Godage; Arghya Deb; Hui Si Kwok; Prashant Singh; Sameek Singh; Jonathan B. Allen; Wenzhi Tian; Pallavi M. Gosavi; Santosh K. Chaudhary; Viktoriya Anokhina; Ellen L. Weisberg; N. Connor Payne; Yao He; Reilly Osadchey; Mrinal Shekhar; Ralph Mazitschek; Matthew G. Rees; Jennifer A. Roth; Qiang Cui; James D. Griffin; Brian B. Liau; Amit Choudhary

Journal: biorxiv

PubMed ID: 40661463

Doi: 10.1101/2025.06.13.659082

Products & Services: PCR Cloning and Subcloning

Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis

Journal: biorxiv

PubMed ID: 40661463

Doi: 10.1101/2025.06.13.659082

Products & Services: PCR Cloning and Subcloning