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Selective fluorination of Fc glycans enhances antibody-mediated effector functions

Authors: Xianyang Wang; Margaryta Gomozkova; Siqi Li; Biswarup Banerjee; Guanghui Zong; Dominique Missiakas; Lai-Xi Wang

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41849397

Doi: 10.1073/pnas.2530653123

Selective fluorination of Fc glycans enhances antibody-mediated effector functions

Authors: Xianyang Wang; Margaryta Gomozkova; Siqi Li; Biswarup Banerjee; Guanghui Zong; Dominique Missiakas; Lai-Xi Wang

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41849397

Doi: 10.1073/pnas.2530653123

A D-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis

Authors: Michael J. Pepi; Shibin Chacko; Gary M. Marqus; Vinayak Singh; Zhe Wang; Kyle Planck; Ryan T. Cullinane; Penchala N. Meka; Deviprasad R. Gollapalli; Thomas R. Ioerger; Kyu Y. Rhee; Gregory D. Cuny; Helena I.M. Boshoff; Lizbeth Hedstrom

Journal: ACS Infectious Diseases

PubMed ID: 35015509

Doi: 10.1021/acsinfecdis.1c00461

Guidelines in the Preparation of Fully Synthetic, Human Single-Domain Antibody Phage Display Libraries

Authors: Mark A. Tornetta; Brian P. Whitaker; Olivia M. Cantwell; Peter N. Haytko; Eileen D. Pisors; Fulai Zhou; Mark L. Chiu

Journal: Antibodies

PubMed ID: 40843683

Doi: 10.3390/antib14030071

An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1challenge in cynomolgus macaques

Authors: Ninaad Lasrado, Liping Wang, Jinyan Liu, Annika Rössler, Jayeshbhai Chaudhari, Qixin Wang, Jonathon J Stone, Francisco Armando Granados-Contreras, Jessica Wu, Dalia N Cabrera-Barragan, Alejandra Waller-Pulido, Samuel J Nangle, Krishna Shah, Reed Boduch, Siddhesh Warke, Anthony Cook, Christopher Kitajewski, Laurent Pessaint, Mark G Lewis, Hanne Andersen, Amanda J Martinot, Ryan P McNamara, Dan H Barouch

Journal: Science Translation Medicine

PubMed ID: 41091914

Doi: 10.1126/scitranslmed.ady2282

Products & Services: Peptide Library Services

Journal of Controlled Release

Authors: Fei Li, Quan Wang, Tingting Wang, Chen Xiong, Ziling Chen, Hanzhi Ouyang, Xiaoding Lou, Fan Xia, Shixuan Wang, Meng Wu, Jun Dai

Journal: Journal of controlled release

Doi: 10.1016/j.jconrel.2025.114337

Products & Services: Plasmid DNA Preparation

A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology

Authors: Lauren Gebhardt, Molica Abel, Jing Zhou, Audrey M Vogt, Bo Hee Shin, Sarah L Herrick Wagman, Ana Santos, Jerome Puginier, Florian M Wurm, Maria J Wurm, Guoying Grace Yan, Adedolapo Adeniyi, Sean K H Lim, Will Somers, Laura Lin, Aaron M D'Antona, Xiaotian Zhong

Journal: Antibodies

PubMed ID: 41133681

Doi: 10.3390/antib 14040087

Products & Services: Protein and Antibody Isolation

Microbial binding module employs sophisticated clustered saccharide patches to selectively adhere to mucins

Authors: Thapakorn Jaroentomeechai, Billy Veloz, Cátia O Soares, Felix Goerdeler, Ana Sofia Grosso, Christian Büll, Rebecca L Miller, Sanae Furukawa, Irene Ginés-Alcober, Víctor Taleb, Pedro Merino, Mattia Ghirardello, Ismael Compañón, Helena Coelho, Jorge S Dias, Renaud Vincentelli, Bernard Henrissat, Hiren Joshi, Henrik Clausen, Francisco Corzana, Filipa Marcelo, Ramon Hurtado-Guerrero, Yoshiki Narimatsu

Journal: Nature Communications

PubMed ID: 41083434

Doi: 10.1038/s41467-025-63756-w

αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models

Authors: Tianci Wang, Yupu Xu, Zhengfeng Zhang, Yaqi Wu, Long Chen, Xiaodong Zheng, Hui Peng, Qiang Zou, Rui Sun, Hongdi Ma, Haoyu Sun, Zhigang Tian & Xiaohu Zheng

Journal: Nature Communications

PubMed ID: 41107262

Doi: 10.1038/s41467-025-64296-z

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade

Authors: Adam J. Grippin, Christiano Marconi, Sage Copling, Nan Li, Chen Braun, Cole Woody, Elliana Young, Priti Gupta, Min Wang, Annette Wu, Seong Dong Jeong, Dhruvkumar Soni, Frances Weidert, Chao Xie, Eden Goldenberg, Andrew Kim, Chong Zhao, Anna DeVries, Paul Castillo, Rishabh Lohray, Michael K. Rooney, Benjamin R. Schrank, Yifan Wang, Yifan Ma, D3CODE Team, …Steven H. Lin

Journal: Nature

PubMed ID: 41125896

Doi: 10.1038/s41586-025-09655-y