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Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma

Authors: Martina Mang Leng Lei, Carmen Oi Ning Leung, Rainbow Wing Hei Leung, Xue Qian Wu, Katherine Po Sin Chung, Catherine Yu Jia Gu, Mandy Sze Man Chan, Wing Ki Chau, Quan Hua Mu, Kai Yu Ng, Man Tong, Jing Ping Yun, Jia Ming Nickolas Teo, Guang Sheng Ling, Patrick Pak Chun Wong, Stephen Lam Chan, Zhe Wen Xiong, Alfred Sze Lok Cheng, Jin Ding, Stephanie Ma, Terence Kin Wah Lee

Journal: Nature Communications

PubMed ID: 41219194

Doi: 10.1038/s41467-025-64860-7.

Products & Services: Mutagenesis Services

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency

Authors: Vinod Tiwari, Byungchang Jin, Olivia Sun, Edwin D J Lopez Gonzalez, Min-Hsuan Chen, Xiwei Wu, Hardik Shah, Andrew Zhang, Mark A Herman, Cassandra N Spracklen, Russell P Goodman, Charles Brenner

Journal: Nature metabolism

PubMed ID: 41238906

Doi: 10.1038/s42255-025-01399-3.

Control of Mycobacterium tuberculosis protein secretion by ESX-4 and the outer membrane EsxUT-EsxEF complex

Authors: Rashmi Ravindran Nair, Virginia Meikle, Swati Dubey, Mikhail Pavlenok, Anna D Tischler, Michael Niederweis

Journal: Nature Communications

PubMed ID: 41266320

Doi: 10.1038/s41467-025-65061-y.

Products & Services: Polyclonal Antibody Services

Interpretable molecular decision-making with DNA-based scalable and memory-efficient tree computation

Authors: Junlan Liu, Qian Tang, Yongqi Han, Jinxing Song, Fei Wang, Pei Guo, Chunhai Fan, Weihong Tan, Da Han

Journal: Nature Communications

PubMed ID: 41271734

Doi: 10.1038/s41467-025-66610-1.

High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures

Authors: Aira F Cabug, Jeremy Chase Crawford, Hayley A McQuilten, Isabelle J H Foo, Lilith F Allen, Deborah Gebregzabher, Robert C Mettelman, Tanya Novak, Janet Chou, Louise C Rowntree, Ruth R Hagen, Abby J Thomson, Genevieve E Martin, Brad Gilbertson, Michael Nt Souter, Fiona James, Emma Goodall, Simone Rizzetto, Tim Flerlage, Xiaoxiao Jia, Lee-Ann Van de Velde, So Young Chang, Fabio Luciani, Ryan S Thwaites, Jason A Trubiano, Tom C Kotsimbos, Allen C Cheng, Adrienne G Randolph, Paul G Thomas, Jianqing Xu, Zhongfang Wang, Thi H O Nguyen, Brendon Y Chua, Lukasz Kedzierski, Katherine Kedzierska

Journal: Nature Communications

PubMed ID: 41285788

Doi: 10.1038/s41467-025-65262-5.

Products & Services: Peptide Synthesis

Comparative analysis of adenovirus, mRNA, and protein vaccines reveals context-dependent immunogenicity and efficacy

Authors: Bakare Awakoaiye, Shiyi Li, Sarah Sanchez, Tanushree Dangi, Nahid Irani, Laura Arroyo, Gabriel Arellano, Shadi Mohammadabadi, Malika Aid, Pablo Penaloza-MacMaster

Journal: JCI Insight

PubMed ID: 41212056

Doi: 10.1172/jci.insight.198069

Products & Services: Custom mRNA synthesis

Genome-Wide Identification of GW5-LIKE Family Revealed the Function of ClGL1 Involved in Fruit and Seed Shape by Mediating Brassinosteroid Signaling in Watermelon

Authors: Peng Tian, Lei Zhang, Jingjing Zhang, Bowen Liu, Wei Liu, Bing Li, Xiurui Gao, Jie Zhang, Yanrong Wu, Yong Xu

Journal: Horticulturae

Doi: 10.3390/horticulturae11111326

Products & Services: Custom DNA/RNA Oligos

TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice

Authors: Kai-Zhao Chen, Zi-Yang Lin, Long-Jun Chen, You-Xi Zhou, Wei Zhang, Hao-Yang Wan, Yong-Kun Huo, Qi Fu, Zi-Qing Gao, Hong-Wei Cheng, Xiao-Dong Ma, Shuai-Shuai Zhang

Journal: Military Medical Research

PubMed ID: 41214839

Doi: 10.1186/s40779-025-00667-3

Products & Services: Protein and Antibody Isolation

Double-stranded DNA deaminase DddAE1347A can increase the efficiency and targeting range of cytidine base editors

Authors: Yuqiang Qian, Fengjiao Hui, Wenchao Niu, Di Wang, Yang Hao, Qingying Meng, Siyu Ren, Deqiang Kong, Heng Gong, Jiayu Wu, Kexin Chen, Muna Alariqi, Junping Gao, Zhanjun Li, Shuangxia Jin

Journal: Genome Biology

PubMed ID: 41250247

Doi: doi.org/10.1186/s13059-025-03849-3

Products & Services: Gene Fragments

RBM39 Contributes to MGMT Maintenance in Response to Temozolomide-Induced DNA Damage

Authors: Vahid Khalaj, Jack T Adams, Solmaz AghaAmiri, Servando Hernandez Vargas, Tyler M Bateman, Sukhen C Ghosh, Majid Momeny, Ali Azhdarinia

Journal: Cancers

PubMed ID: 41300971

Doi: 10.3390/cancers17223604

Products & Services: Protein Electrophoresis and Western