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Pmt4 recognizes two separate acceptor sites to O-mannosylate in the S/T-rich regions of substrate proteins

Authors: Minge Du, Zuanning Yuan, Amanda Kovach, Meinan Lyu, Huilin Li

Journal: Nature Communications

PubMed ID: 41188226

Doi: 10.1038/s41467-025-64729-9.

Products & Services: Protein and Antibody Isolation

StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models

Authors: Massimo Saini, Francesc Castro-Giner, Adriana Hotz, Magdalena K Sznurkowska, Manuel Nüesch, François M Cuenot, Selina Budinjas, Gilles Bilfeld, Ece Su Ildız, Karin Strittmatter, Ilona Krol, Zoi Diamantopoulou, Aino Paasinen-Sohns, Maria Waldmeier, Rafaela Cássio, Susanne Kreutzer, Zacharias Kontarakis, Ana Gvozdenovic, Nicola Aceto

Journal: Cell

PubMed ID: 41205600

Doi: 10.1016/j.cell.2025.10.007.

Products & Services: Gene Synthesis

Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter

Authors: Victor Hugo Pérez Carrillo, Margot Di Cesare, Dania Rose-Sperling, Waqas Javed, Hannes Neuweiler, Julien Marcoux, Cédric Orelle, Jean-Michel Jault, Ute A Hellmich

Journal: Nature Communications

PubMed ID: 41219214

Doi: 10.1038/s41467-025-65037-y.

A yeast surface display platform for characterizing CAR T cell responses to cancer antigens

Authors: Marcus Deichmann, Giovanni Schiesaro, Keerthana Ramanathan, Katrine Zeeberg, Nanna M T Koefoed, Maria Ormhøj, Rasmus U W Friis, Ryan T Gill, Sine R Hadrup, Emil D Jensen, Michael K Jensen

Journal: Nature Communications

PubMed ID: 41271729

Doi: 10.1038/s41467-025-65236-7.

Products & Services: Peptide Synthesis

A bispecific antibody targeting PD-L1/TNFR2 increases tumor targeting and enhances antitumor efficacy in colorectal cancer

Authors: Xiaozhen Kang, Peng Qian, Yifeng Han, Mengdi Wu, Yuxin Li, Chun Xu, Jiwu Wei

Journal: Journal for ImmunoTherapy of Cancer

PubMed ID: 41238220

Doi: https://doi.org/10.1136/jitc-2025-013001

Products & Services: Catalog Antibodies

Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors

Authors: Chunlong Ma; Jun Wang

Journal: ACS pharmacology & translational science

PubMed ID: 35178512

Doi: 10.1021/acsptsci.1c00240

Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors

Authors: Chunlong Ma; Jun Wang

Journal: ACS pharmacology & translational science

PubMed ID: 35178512

Doi: 10.1021/acsptsci.1c00240

De N ovo -Designed Miniprotein Inhibits the Enzymatic Activity of the SARS-CoV 2 Main Protease

Authors: Tayn E. Lima; Emerson G. Moreira; Danilo F. Co lho; Carlos H. B. Cruz; Rafael Dhalia; Bruno H. S. Leite; L cya S. Xavier; Marta Perez Illana; Gabriel L. Wallau; Isabelle F. T. Viana; Roberto D. Lins

Journal: Journal of chemical information and modeling

PubMed ID: 41060276

Doi: 10.1021/acs.jcim.5c01708

The Sobering Sting: Oleoyl Serotonin Is a Novel Stephanoconus Snail Venom-Derived Antagonist of Cannabinoid Receptors That Counteracts Learning and Memory Deficits

Authors: Dongchen An; Guilherme Salgado Carrazoni; Ben-Hur Souto das Neves; Rudi D Hooge; Steve Peigneur; Jan Tytgat

Journal: Biomedicines

PubMed ID: 38398056

Doi: 10.3390/biomedicines12020454

Products & Services: Custom Vector Construction

Genetics of cystogenesis in base edited human organoids reveal therapeutic strategies for polycystic kidney disease

Authors: Courtney E. Vishy; Chardai Thomas; Thomas Vincent; Daniel K. Crawford; Matthew M. Goddeeris; Benjamin S. Freedman

Journal: Cell Stem Cell

PubMed ID: 38579684

Doi: 10.1016/j.stem.2024.03.005

Products & Services: Plasmid DNA Preparation