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页码: 178/5358 每页显示数量

Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening

Authors: Jasmin C. Aschenbrenner; Andre Schutzer de Godoy; Michael Fairhead; Charles W.E. Tomlinson; Max Winokan; Blake H. Balcomb; Eda Capkin; Anu V. Chandran; Mathew Golding; Lizbe Koekemoer; Ryan M. Lithgo; Peter G. Marples; Xiaomin Ni; Warren Thompson; Conor Wild; Mary-Ann E. Xavier; Daren Fearon; Frank von Delft

Journal: biorxiv

PubMed ID: 39229067

Doi: 10.1101/2024.08.23.609196

Discovery of a 6-Aminobenzo[ b ]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities

Authors: Patrik Oleksak; David Rysanek; Marketa Vancurova; Pavla Vasicova; Alexandra Urbancokova; Josef Novak; Dominika Maurencova; Pavel Kashmel; Jana Houserova; Romana Mikyskova; Ondrej Novotny; Milan Reinis; Pavel Juda; Miroslav Hons; Jirina Kroupova; David Sedlak; Tetyana Sulimenko; Pavel Draber; Marketa Chlubnova; Eugenie Nepovimova; Kamil Kuca; Miroslav Lisa; Rudolf Andrys; Tereza Kobrlova; Ondrej Soukup; Jiri Janousek; Lukas Prchal; Jiri Bartek; Kamil Musilek; Zdenek Hodny

Journal: ACS pharmacology & translational science

PubMed ID: 39296273

Doi: 10.1021/acsptsci.4c00190

Products & Services: Monoclonal Antibody Services

Proteasome gene expression is controlled by coordinated functions of multiple transcription factors

Authors: Jennifer E Gilda, Asrafun Nahar, Dharanibalan Kasiviswanathan, Nadav Tropp, Tamar Gilinski, Tamar Lahav, Dina Alexandrovich, Yael Mandel-Gutfreund, Soyeon Park, Shenhav Shemer

Journal: J Cell Biol

PubMed ID: 38767572

Doi: 10.1083/jcb.202402046

Products & Services: Catalog Antibodies

Regulation of Glandular Size and Phytoalexin Biosynthesis by a Negative Feedback Loop in Cotton

Authors: Wen-Kai Wu, Gui-Bin Nie, Jia-Ling Lin, Jia-Fa Huang, Xiao-Xiang Guo, Mei Chen, Xin Fang, Ying-Bo Mao, Yan Li, Ling-Jian Wang, Xiao-Yuan Tao, Yiqun Gao, Zuo-Ren Yang, Jin-Quan Huang

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

PubMed ID: 38840438

Doi: 10.1002/advs.202403059. Epub 2024 Jun 5.

Products & Services: Protein and Antibody Isolation

hypocretin-1/hypocretin receptor 1 regulates neuroplasticity and cognitive function through hippocampal lactate homeostasis in depressed model

Authors: Bing Chen , Kangyu Jin , Jingyi Dong , Shangping Cheng , Lingzhuo Kong , Shaohua Hu , Zuobing Chen, Jing Lu

Journal: Advanced Science

PubMed ID: 39119889

Doi: 10.1002/advs.202405354

Products & Services: Protein Electrophoresis and Western Protein Electrophoresis and Western

Rupatadine-inhibited OTUD3 promotes DLBCL progression and immune evasion through deubiquitinating MYL12A and PD-L1

Authors: Ying Sui , Ziyang Shen, Xiaoyou Li 1, Ya Lu , SiTong Feng , Rong Ma, Jianzhong Wu , Changwen Jing, Zhuo Wang, Jifeng Feng , Haixia Cao

Journal: Cell death & disease

PubMed ID: 39097608

Doi: 10.038/s41419-024-06941-x

Products & Services: Protein and Antibody Isolation

Spatiotemporal coordination of antigen presentation and co-stimulatory signal for enhanced anti-tumor vaccination

Authors: Sha Peng , Yumeng Yan , Kenji Ogino , Guanghui Ma , Yufei Xia

Journal: Journal of controlled release

PubMed ID: 39153722

Doi: 10.1016/j.jconrel.2024.08.025.

Products & Services: Peptide Synthesis

A low-molecular-weight α-glucan from edible fungus Agaricus blazei Murrill activates macrophage TFEB-mediated antibacterial defense to combat implant-associated infection

Authors: Qishan Wang , Yuehong Wang , Yihao Liu , Kai Yuan , Yixuan Lin , Xian Qian , Hongyan Pei , Liangliang Weng , Kaijian Fan , Yihe Hu , Yiqi Yang

Journal: Carbohydrate Polymers

Doi: 10.1016/j.carbpol.2024.122659

Products & Services: Protein Electrophoresis and Western

siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice

Authors: Yi Ding 1, Qiu-Bing Chen , Hui Xu , Dilare Adi , Yi-Wen Ding , Wen-Jun Luo , Wen-Zhuo Zhu , Jia-Chen Xu , Xiaolu Zhao , Xiong-Jie Shi , Jie Luo , Hao Yin , Xiao-Yi Lu

Journal: Journal of lipid research

PubMed ID: 39173829

Doi: 10.1016/j.jlr.2024.100626

Products & Services: Custom RNAi Services

Channelrhodopsins with distinct chromophores and binding patterns

Authors: Yuanyue Shan , Liping Zhao , Meiyu Chen , Xiao Li , Mingfeng Zhang , Duanqing Pei

Journal: Nature Communications

PubMed ID: 39181878

Doi: 10.1038/s41467-024-51811-x

Products & Services: Protein and Antibody Isolation