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Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket

Authors: Johannes Morstein , Victoria Bowcut , Micah Fernando , Yue Yang , Lawrence Zhu , Meredith L Jenkins , John T Evans , Keelan Z Guiley , D Matthew Peacock , Sophie Krahnke , Zhi Lin , Katrine A Taran , Benjamin J Huang , Andrew G Stephen , John E Burke , Felice C Lightstone , Kevan M Shokat

Journal: Cell

PubMed ID: 39255801

Doi: 10.1016/j.cell.2024.08.017

Products & Services: DNA Sequencing

Accelerated discovery and miniaturization of novel single-stranded cytidine deaminases

Authors: Jiacheng Deng,† , Xueyuan Li,† , Hao Yu,† , Lin Yang1, Ziru Wang1, Wenfeng Yi, Ying Liu, Wenyu Xiao, Hongyong Xiang, Zicong Xie, Dongmei Lv, Hongsheng Ouyang, Daxin Pang, * and Hongming Yuan

Journal: Nucleic Acids Research

PubMed ID: 39271120

Doi: doi.org/10.1093/nar/gkae800

Products & Services: Gene Synthesis

Rational design of a DNA-launched live attenuated vaccine against human enterovirus 71

Authors: Rong-Rong Zhang 1, Meng-Jiao He 1, Chao Zhou 1, Yan-Peng Xu 1, Wei Tang 1, Tian-Shu Cao 1, Zheng-Jian Wang , Mei Wu , Tao Ming , Yi-Jiao Huang , Meng-Xu Sun , Hui Zhao , Yong-Qiang Deng , Xiao-Feng Li , Bin Wang , Qing Ye , Cheng-Feng Qin

Journal: VIROLOGICA SINICA

PubMed ID: 39306193

Doi: 10.1016/j.virs.2024.09.008

Products & Services: Peptide Tools

Crystal structure and nucleic acid binding mode of CPV NSP9: implications for viroplasm in Reovirales

Authors: Yeda Wang , Hangtian Guo , Yuhao Lu , Wanbin Yang , Tinghan Li , Xiaoyun Ji

Journal: Nucleic Acids Research

PubMed ID: 39287123

Doi: doi.org/10.1093/nar/gkae803

Products & Services: Gene Synthesis

Efficient circularization of protein-encoding RNAs via a novel cis-splicing system

Authors: Shaojun Qi , Huiming Wang , Guopeng Liu , Qianshan Qin , Peng Gao , Bo Ying

Journal: Nucleic Acids Research

PubMed ID: 39162233

Doi: 10.1093/nar/gkae711

Products & Services: Gene Synthesis

Intein splicing efficiency and RadA levels can control the mode of archaeal DNA replication

Authors: Geraldy L S Liman , Christopher W Lennon , Jaylin L Mandley , Alina M Galyon , Kelly M Zatopek , Andrew F Gardner , Thomas J Santangelo

Journal: SCIENCE ADVANCES

PubMed ID: 39292776

Doi: 10.1126/sciadv.adp4995

Products & Services: Gene Synthesis Mutagenesis Services

Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression

Authors: Haley E Adcox , Jason R Hunt , Paige E Allen , Thomas E Siff , Kyle G Rodino , Andrew K Ottens , Jason A Carlyon

Journal: Nature Communications

PubMed ID: 39277599

Doi: 10.1038/s41467-024-52119-6

Products & Services: Custom Vector Construction Codon Optimization

Lysophospholipid signaling coordinates outer membrane homeostasis in Escherichia coli

Authors: Gerald R. Enverso; M. Stephen Trent

Journal: MBio

PubMed ID: 41979331

Doi: 10.1128/mbio.00567-26

Products & Services: Gene Synthesis

Pleiotropic Anti-Cancer Activities of Novel Non-Covalent Thioredoxin Reductase Inhibitors Against Triple Negative Breast Cancer

Authors: Brenna Flowers; Abigail Rullo; An Zhang; Keacha Chang; Valentina Z. Petukhova; Sammy Y. Aboagye; Francesco Angelucci; David L. Williams; Steven Kregel; Pavel Petukhov; Irida Kastrati

Journal: Free radical biology & medicine

PubMed ID: 39643141

Doi: 10.1016/j.freeradbiomed.2024.12.010

Pleiotropic Anti-Cancer Activities of Novel Non-Covalent Thioredoxin Reductase Inhibitors Against Triple Negative Breast Cancer

Authors: Brenna Flowers; Abigail Rullo; An Zhang; Keacha Chang; Valentina Z. Petukhova; Sammy Y. Aboagye; Francesco Angelucci; David L. Williams; Steven Kregel; Pavel Petukhov; Irida Kastrati

Journal: Free radical biology & medicine

PubMed ID: 39643141

Doi: 10.1016/j.freeradbiomed.2024.12.010