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Tryptoline stereoprobe elaboration identifies inhibitors of the GRPEL1–HSPA9 complex

Authors: Rachel E Hayward, Raymond F Berkeley, Zijian Gao, Maximilian Garhammer, Marc A Morizono, Evert Njomen, Haoxin Li, Kristen E DeMeester, Victor Cociorva, Mark A Herzik Jr, F Ulrich Hartl, Bruno Melillo, Benjamin F Cravatt

Journal: Nature Chemical Biology

PubMed ID: 42888267

Doi: 10.1038/s41589-026-02348-1

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Structural basis of an endoplasmic reticulum EMC:Spf1 insertase–dislocase complex

Authors: Carolin J Klose, J Rajan Prabu, Emma J Fenech, Bastian Bräuning, Ida Baydar, Barbara Steigenberger, Susanne von Gronau, Sivan Arad, Christine R Langlois, Maya Schuldiner, Brenda A Schulman, Matthias J Feige

Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY

PubMed ID: 42870022

Doi: 10.1038/s41594-026-01883-8

Products & Services: Peptide Synthesis

Chromatin interaction landscape of epimorphic regeneration in teleost fish

Authors: Xiaohui Jia, Xianglei Zhang, Weifeng Lin, Tengfei Ren, Shiqi Liu, Yufei Lou, Wei Wang

Journal: Science advences

PubMed ID: 42853912

Doi: 10.1126/sciadv.aeh2087

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tRNA dosage regulates lineage dependency and resistance in prostate cancer

Authors: Yeon Soo Kim, Sonali Arora, Dave Young, Ava Tsou, Amy Shiuan, Cynthia L Wladyka, Dmytro Rudoy, Jin Yeong Kim, Jennifer A Waters, Samantha L Schuster, Ilsa M Coleman, Mridu Kapur, Marek Sobczyk, Christopher D Katanski, Amin M Bayat Tork, Wen Zhang, Peter S Nelson, Gavin Ha, Michael C Haffner, Eva Corey, Colm Morrissey, Yuzhuo Wang, Arvind R Subramaniam, John K Lee, Susan L Ackerman, Tao Pan, Andrew C Hsieh

Journal: Nature

PubMed ID: 42844465

Doi: 10.1038/s41586-026-11153-8

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Development and application of a smartphone-based thermal contrast amplification reader for photothermal lateral flow immunoassays

Authors: Jiajie Liang, Peijun Teng, Lei Wu, Wanli Liang, Qifang Song, Guanbo He, Yanqiang Hao, Haorong He, Yaqi Wang, Yong He, Xiaoli Zhang, Xiangming Peng, Wei Xiao, Bing Zhu, Yong Tang, Daxiang Cui, Jianfu Zhao

Journal: microsystems & nanoengineering

PubMed ID: 42859136

Doi: 10.1038/s41378-026-01450-7.

PTPRS mediates invasion of tetanus neurotoxin into the central nervous system

Authors: Pengsheng Chen, Huan Wang, John Manion, Jonas Zähringer, Junjie Liang, Aisha Mohammed, Leo Zhao, Jie Zhang, Yuankai Wang, Kang Wang, Pyung-Gang Lee, Geoffrey Masuyer, Karla J F Satchell, Joseph S Brunzelle, Taekjip Ha, Pål Stenmark, Min Dong

Journal: Cell

PubMed ID: 42869022

Doi: 10.1016/j.cell.2026.09.026

Host cell traversal by Plasmodium parasites drives sterilizing T cell-mediated immunity following immunization

Authors: Ana Rodrigues, António M Mendes, Rute Gonçalves, Helena Nunes-Cabaço, Sofia Marques, Nuno Valente-Leal, Daniel Gomes da Costa, Cristina Ferreira, Marc Veldhoen, Miguel Prudêncio, Maria M Mota, Ângelo Ferreira Chora

Journal: Nature Microbiology

PubMed ID: 42816581

Doi: 10.1038/s41564-026-02477-2.

Products & Services: Peptide Synthesis

Molecular Programming of Steric Tags for Controlled Nanopore Translocation toward Precision Clinical Diagnostic Assistance

Authors: Heng Liu, Shijun Lin, Minglun Li, Hao Fang, Zhicheng Zhang, Ruwei Wei, Yan Zhang, Jun Dai, Tao Liu, Fan Xia, Xiaoding Lou

Journal: Journal of the American Chemical Society

Doi: doi.org/10.1021/jacs.6c15448

Products & Services: Peptide Synthesis

Dense RNA motif modifications enable robust in vivo prime editing and enhance efficiencies of diverse editing systems

Authors: Xinlin Lei, Didi Chen, Kun Zhang, Xiyu Liu, Qiubing Chen, Yizhou Zhang, Ruijin Ji, Jicheng Zhu, Qingyi Zhang, Ying Zhang, Hao Yin

Journal: nature biomedical engineering

PubMed ID: 42728339

Doi: 10.1038/s41551-026-01787-4

Products & Services: Gene Synthesis

Bioengineered Protein Contrast Agents with Dual-Targeting and Stroma-PrimingCapabilities to Overcome Biophysical Barriers in Pancreatic Cancer

Authors: Ruofan Hu, Zichun Chen, Sensen Zhou, Yang Yuan, Dan Zhu, Yikai Tang, Weizhi Chen, Xiqun Jiang

Journal: Chemical Engineering Journal

Doi: org/10.1016/j.cej.2026.182132.

Products & Services: Gene Synthesis