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Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection

Authors: Rui Chao, Yexin Wang, Zhan Liu, Tianhao Wan, Yi Mao, Xinru Xie, Lei Sun, Weifeng Xu, Xuzhuo Chen, Shanyong Zhang

Journal: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PubMed ID: PMC12488209

Doi: 10.3892/ijmm.2025.5647

Products & Services: Protein and Antibody Isolation

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender

Authors: Yan Huang, Biao Hu, Ya Liu, Ling-Qi Xie, Yu Dai, Yu-Ze An, Xin-Yi Peng, Ya-Lun Cheng, Yi-Fan Guo, Wei-Hong Kuang, Yao Xiao, Xin Chen, Yong-Jun Zheng, Gen-Qing Xie, Jian-Ping Wang, Hui Peng, Xiang-Hang Luo

Journal: Cell metabolism

PubMed ID: 41344322

Doi: doi.org/10.1016/j.cmet.2025.11.002

Products & Services: Nucleic Acid Purification

RING- Type E3 Ligase OsRFPH2- 6 Ubiquitinates Nuclear Factor Y Subunit OsNF- YA1 to Suppress Rice Immunity

Authors: Yan Bi, Leeza Tariq, Hui Wang, Yuqing Yan, Dayong Li, Fengming Song

Journal: Molecular plant pathology

PubMed ID: 41424058

Doi: 10.1111/mpp.70193

Products & Services: Catalog Antibodies

Semi-inductive dataset construction and framework optimization for practical drug target interaction prediction with ScopeDTI

Authors: Yigang Chen; Xiang Ji; Ziyue Zhang; Zihao Zhu; Yuming Zhou; Chang Su; Yang-Chi-Dung Lin; Hsi-Yuan Huang; Kangping Wei; Yi Lai; Ke Chen; Xingqiao Lin; Yangyi Zhang; Jiehui Fu; Yixian Huang; Shidong Cui; Shih-Chung Yen; Tao Zhang; Arieh Warshel; Hsien-Da Huang

Journal: Nature Communications

PubMed ID: 41390462

Doi: 10.1038/s41467-025-66311-9

Products & Services: Protein Electrophoresis and Western

Structural basis of Neisseria meningitidis quinol dependent nitric oxide reductase activation by dimerization

Authors: Chai C. Gopalasingam; Haruka Egami; Hideki Shigematsu; Masatora Sakaue; Kouki Fukumoto; Christoph Gerle; Masaki Yamamoto; Yoshitsugu Shiro; Kazumasa Muramoto; Takehiko Tosha

Journal: Communications Biology

PubMed ID: 41896389

Doi: 10.1038/s42003-026-09754-0

Products & Services: Plasmid DNA Preparation

From Multi-Species Screening to Targeted Investigation: Discovery of ACE Inhibitory Peptides in Gigantidas platifrons via Peptidomics, Virtual Screening, and Molecular Dynamics Simulations

Authors: Haorui Zhang; Yuhong Ouyang; Qishan Suo; Hao Chen; Jie Cui; Yang Yue

Journal: Molecules

PubMed ID: 41828750

Doi: 10.3390/molecules31050757

Products & Services: Peptide Synthesis

Targeting Protein Protein Interactions (PPIs) to Drive Functional Annotation: An Integrative Methodology to Study Senescence-Associated PPIs Using TMPRSS11a as Model Interactor

Authors: Roberto Rosales-Rojas; Christian Fern ndez; Mariela Gonz lez-Avenda o; Ariela Vergara-Jaque; M nica C ceres

Journal: Biomolecules

PubMed ID: 42194062

Doi: 10.3390/biom16050714

Nuclear effects play an important role in determining codon usage-dependent human gene expression

Authors: Renu Garg, Pancheng Xie, Jiabin Duan, Huan Liu, Yi Liu

Journal: Nature Communications

PubMed ID: 41339630

Doi: 10.1038/s41467-025-65907-5

Products & Services: Gene Synthesis

Structural basis of microtubule-mediated signal transduction

Authors: Sung Ryul Choi, Thorsten B Blum, Matteo Giono, Bibhas Roy, Ioannis Vakonakis, Dominic Schmid, Nicole Oelgarth, Apisha Ranganathan, Alvar D Gossert, G V Shivashankar, Alfred Zippelius, Michel O Steinmetz

Journal: Cell

PubMed ID: 41365297

Doi: 10.1016/j.cell.2025.11.011

Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors

Authors: Michael Launspach, Julia Macos, Shoaib Afzal, Janik Hohmann, Marc L Appis, Maximilian Pilgram, Stefanie Beez, Emily Ohlendorf, Casper F T van der Ven, Chahrazad Lachiheb, Karin Töws, Lena Andersch, Marvin Jens, Felix Zirngibl, Jonas Kath, Maria Stecklum, Elias Rodriguez-Fos, Kathleen Anders, Dimitrios L Wagner, Anton G Henssen, Ralf Kühn, Angelika Eggert, Annette Künkele

Journal: Nature Communications

PubMed ID: 41366257

Doi: 10.1038/s41467-025-67328-w