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A coronavirus assembly inhibitor that targets the viral membrane protein

Authors: Manon Laporte; Dirk Jochmans; Doroth e Bardiot; Lowiese Desmarets; Oliver J. Debski-Antoniak; Giulia Mizzon; Rana Abdelnabi; Pieter Leyssen; Winston Chiu; Zhikuan Zhang; Norimichi Nomura; Sandro Boland; Umeharu Ohto; Yannick Stahl; Jurgen Wuyts; Steven De Jonghe; Annelies Stevaert; Martijn J. van Hemert; Brenda W. Bontes; Patrick Wanningen; G. J. Mirjam Groenewold; Aneta Zegar; Katarzyna Owczarek; Sanjata Joshi; Mohamed Koukni; Philippe Arzel; Hugo Klaassen; Jean-Christophe Vanherck; Ilse Vandecaetsbeek; Niels Cremers; Kim Donckers; Thibault Francken; Tina Van Buyten; Jasper Rymenants; Joost Schepers; Krzysztof Pyrc; Rolf Hilgenfeld; Jean Dubuisson; Berend-Jan Bosch; Frank Van Kuppeveld; Cecilia Eydoux; Etienne Decroly; Bruno Canard; Lieve Naesens; Birgit Weynand; Eric J. Snijder; Sandrine Belouzard; Toshiyuki Shimizu; Ralf Bartenschlager; Daniel L. Hurdiss; Arnaud Marchand; Patrick Chaltin; Johan Neyts

Journal: Nature

PubMed ID: 40140569

Doi: 10.1038/s41586-025-08773-x

A Modified Variant of Fasciola hepatica FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

Authors: Riseilly Ramos-Nieves; Albersy Armina-Rodriguez; Maria Del Mar Figueroa-Gispert; Ghalib Figueroa-Qui ones; Carlimar Ocasio-Malav ; Ana M. Espino

Journal: Vaccines

PubMed ID: 40432154

Doi: 10.3390/vaccines13050545

A Modified Variant of Fasciola hepatica FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

Authors: Riseilly Ramos-Nieves; Albersy Armina-Rodriguez; Maria Del Mar Figueroa-Gispert; Ghalib Figueroa-Qui ones; Carlimar Ocasio-Malav ; Ana M. Espino

Journal: Vaccines

PubMed ID: 40432154

Doi: 10.3390/vaccines13050545

De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors

Authors: Jiayao Yan; Liqing Zhong; Xiaotong Chen; Lin Li; Fangcen Liu; Lei Lei; Mengchao An; Xiao Wei; Ying Wang; Tianran Chen; Jingyi Guo; Jie Shao; Xiaoxiao Yu; Yingjie Zhao; Rutian Li; Qin Liu; Baorui Liu

Journal: Journal of translational medicine

PubMed ID: 41267074

Doi: 10.1186/s12967-025-07316-2

De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors

Journal: Journal of translational medicine

PubMed ID: 41267074

Doi: 10.1186/s12967-025-07316-2

Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus

Authors: Yansi Xian, Bin Liu, Tao Shen, Lin Yang, Rui Peng, Hongdou Shen, Xueying An, Yutian Wang, Yu Ben, Qing Jiang, Baosheng Guo

Journal: Bone Res

PubMed ID: 40025004

Doi: 10.1038/s41413-024-00399-5

Products & Services: Protein and Antibody Isolation

Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs

Authors: Jibin Cui , Qingyun Zheng , Yicheng Weng , Xiaoguo Zhai , Zhen Su , Yunxiang Du , Xiaoxiong Wei , Yuanyuan Yu , Qian Qu , Man Pan

Journal: Analytical Chemistry

PubMed ID: 40000409

Doi: doi.org/10.1002/anie.202501488

Products & Services: Codon Optimization Gene Synthesis

Rational Design Assisted by Evolutionary Engineering Allows (De)Construction and Optimization of Complex Phenotypes in Pseudomonas putida KT2440

Authors: Blas Blázquez, Juan Nogales

Journal: Microbial biotechnology

PubMed ID: 40126873

Doi: 10.1111/1751-7915.70132

Products & Services: Gene Synthesis

Structural basis for the allosteric activation of Lon by the heat shock protein LarA

Authors: Hsiu-Jung Wang, Yun-Erh Kuan, Meng-Ru Ho, Chung-I Chang

Journal: Nature Communications

PubMed ID: 40044692

Doi: 10.1038/s41467-025-57482-6

Products & Services: Custom Vector Construction

Integration of multi-omics data accelerates molecular analysis of common wheat traits

Authors: Ning Zhang, Li Tang, Songgang Li, Lu Liu, Mengjuan Gao, Sisheng Wang, Daiying Chen, Yichao Zhao, Ruiqing Zheng, Armin Soleymaniniya, Lingran Zhang, Wenkang Wang, Xia Yang, Yan Ren, Congwei Sun, Mathias Wilhelm, Daowen Wang, Min Li, Feng Chen

Journal: Nature Communications

PubMed ID: 40038279

Doi: 10.1038/s41467-025-57550-x

Products & Services: Molecular Biology Tools