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Generation of a Novel High-Affinity Antibody Binding to PCSK9 Catalytic Domain with Slow Dissociation Rate by CDR-Grafting, Alanine Scanning and Saturated Site-Directed Mutagenesis for Favorably Treating Hypercholesterolemia

Authors: Zhengli Bai, Menglong Xu, Ying Mei, Tuo Hu, Panpan Zhang, Manman Chen, Wenxiu Lv, Chenchen Lu, Shuhua Tan

Journal: Biomedicines

PubMed ID: 34944600

Doi: 10.3390/biomedicines9121783

Products & Services: Mammalian Expression

Methodology to Quantify Collagen Subtypes and Crosslinks: Application in Minipig Cartilages

Authors: Benjamin J Bielajew, Jerry C Hu, Kyriacos A Athanasiou

Journal: Cartilage

PubMed ID: 34823380

Doi: 10.1177/19476035211060508

Products & Services: Catalog Peptides

Label-free analytical characterization of brazzein produced with the filamentous fungus Trichoderma reesei

Authors: Dominik Mojzita; Nina Aro; Juha Kontturi; Martin K gler; Emilia Nordlund; Waltteri Hosia; Marco G. Casteleijn

Journal: Frontiers in bioengineering and biotechnology

PubMed ID: 41459251

Doi: 10.3389/fbioe.2025.1688495

High-throughput Microwell-seq 2.0 profiles massively multiplexed chemical perturbation

Authors: Haide Chen, Yuan Liao, Guodong Zhang , Zhongyi Sun, Lei Yang, Xing Fang, Huiyu Sun, Lifeng Ma, Yuting Fu, Jingyu Li, Qile Guo, Xiaoping Han, Guoji Guo

Journal: Cell Discov

PubMed ID: 34750394

Doi: 10.1038/s41421-021-00333-7

Products & Services: Custom DNA/RNA Oligos

Bioinspired gelatin/bioceramic composites loaded with bone morphogenetic protein-2 (BMP-2) promote osteoporotic bone repair

Authors: M C Echave, I Erezuma, N Golafshan, M Castilho, F B Kadumudi, C Pimenta-Lopes, F Ventura, A Pujol, J J Jimenez, J A Camara, R Hernáez-Moya, L Iturriaga, L Sáenz Del Burgo, I Iloro, M Azkargorta, F Elortza, R Lakshminarayanan, T H Al-Tel, P García-García, R Reyes, A Delgado, C Évora, J L Pedraz, A Dolatshahi-Pirouz, G Orive

Journal: Biomater Adv

PubMed ID: 35513949

Doi: 10.1016/j.msec.2021.112539

Products & Services: ELISA Kits

Design of a Novel Fab-Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use

Authors: Chunyu Wang, Jiaxu Hong, Zhenlin Yang, Xujiao Zhou, Yuhan Yang, Yu Kong, Binfan Chen, Huifang Wu, Bin-Zhi Qian, Dimiter S Dimitrov, Xingtao Zhou, Yanling Wu, Tianlei Ying

Journal: Small Methods

PubMed ID: 35174992

Doi: 10.1002/smtd.202100966

Products & Services: Mammalian Expression

Vertical transmission of maternal COVID-19 antibodies after CoronaVac vaccine: A case report

Authors: Bruno Thizon Menegali, Fabiana Schuelter-Trevisol, Alexandre Naime Barbosa, Talita Menegali Izidoro, Otto Henrique May Feurschuette, Chaiana Esmeraldino Mendes Marcon, Daisson José Trevisol

Journal: Rev Soc Bras Med Trop

PubMed ID: 34787263

Doi: 10.1590/0037-8682-0385-2021

Products & Services: Protein and Antibody Reagents

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Authors: Pan Pan; Miaomiao Shen; Zhenyang Yu; Weiwei Ge; Keli Chen; Mingfu Tian; Feng Xiao; Zhenwei Wang; Jun Wang; Yaling Jia; Wenbiao Wang; Pin Wan; Jing Zhang; Weijie Chen; Zhiwei Lei; Xin Chen; Zhen Luo; Qiwei Zhang; Meng Xu; Geng Li; Yongkui Li; Jianguo Wu

Journal: Nature Communications

PubMed ID: 34341353

Doi: 10.1038/s41467-021-25015-6

A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling

Authors: Zheyue Wang; Qi Tang; Bende Liu; Wenqing Zhang; Yufeng Chen; Ningfei Ji; Yan Peng; Xiaohui Yang; Daixun Cui; Weiyu Kong; Xiaojun Tang; Tingting Yang; Mingshun Zhang; Xinxia Chang; Jin Zhu; Mao Huang; Zhenqing Feng

Journal: Journal of biomedical research

PubMed ID: 36992606

Doi: 10.7555/JBR.36.20220221

Structure and activation mechanism of the hexameric plasma membrane H+-ATPase

Authors: Peng Zhao, Chaoran Zhao, Dandan Chen, Caihong Yun, Huilin Li, Lin Bai

Journal: Nat Commun.

PubMed ID: 34750373

Doi: 10.1038/s41467-021-26782-y

Products & Services: Protein and Antibody Isolation