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A CLOCK-targeting lncRNA induces trained immunity against tuberculosis

Authors: Shanshan Yu, Qiyao Chai, Zhe Lu, Changgen Qiu, Yanzhao Zhong, Yiru Wang, Zehui Lei, Lihua Qiang, Yingxu Fang, Xinwen Zhang, Bingxi Li, Mengqiu Gao, Lingqiang Zhang, Gong Cheng, Jing Wang, Cui Hua Liu, Yu Pang

Journal: Cell Host & Microbe

PubMed ID: 41475336

Doi: 10.1016/j.chom.2025.12.002

Products & Services: Gene Synthesis

Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

Authors: S Haydar, R Bednarz, P Laurette, I Sobitov, N Díaz I Pedrosa, P Videm, T Lueneburg, S Kuß, H Lahm, M Dreßen, M Krane, C Schmidt, B A Grüning, N Voigt, K Streckfuss-Bömeke, R Gilsbach

Journal: Nature communications

PubMed ID: 41526351

Doi: 10.1038/s41467-025-67220-7

Products & Services: Synthetic Guide RNA

Functional and Mechanistic Investigation of a Distinct DUF6895 Family Epimerase Involved in Lasso Peptide Modification

Authors: Menghan Shi, Yuwei Duan, Shao-Yang Hou, Liangxu Xie, Weifeng Sun, Liubin Feng, Youming Zhang, Xiaoying Bian, and Guannan Zhong

Journal: ACS Catalysis

Doi: 10.1021/acscatal.5c08590

Products & Services: Peptide Synthesis

Screening for novel variable domains of the heavy chains of heavy-chain antibodies targeting different epitopes of thrombomodulin and Luminex fluorescence immunoassay for soluble thrombomodulin

Authors: Congcong Jia, Min Zhu, Yuelan He, Meixiang Yu, Xinyi Xia, Weiwei Ji, Xiang Cao, Jianzhong Lu, Hai Zhang

Journal: International Journal of Biological Macromolecules

PubMed ID: 41314569

Doi: 10.1016/j.ijbiomac.2025.149289

Products & Services: Gene Synthesis Peptide Synthesis

Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations

Authors: Shiming Gan, Yangyang Li, Lin Yin, Xiaotong Yang, Chen Lou, Sisi Li, Mingde Lin, Xin Li, Wenchao Xu, Jiaming Zhou, Peiran Hu, Zhendong Yao, Yuan Yuan, Jianzhong Sheng, Chen Zhang, Wei Yang, Youjiang Li, Hefeng Huang

Journal: EMBO Molecular Medicine

PubMed ID: 41618099

Doi: 10.1038/s44321-026-00374-z

Products & Services: Protein Electrophoresis and Western

The visual system of the longest-living vertebrate, the Greenland shark

Authors: Lily G Fogg, Emily Tom, Maxime Policarpo, William Cho, Fangyuan Gao, Doreen Hii, Aaron E Fawcett, Nicolas Boileau, Amalie Bech-Poulsen, Kirstine F Steffensen, Cherlyn J Ng, Peter G Bushnell, John Fleng Steffensen, Richard Brill, Walter Salzburger, Dorota Skowronska-Krawczyk

Journal: Nature Communications

PubMed ID: 41491153

Doi: 10.1038/s41467-025-67429-6

Products & Services: Peptide Synthesis

Restoration of ovarian endocrine function with encapsulated immune-isolated human ovarian xenograft in ovariectomized mice

Authors: Margaret A Brunette, Monica A Rionda, Delaney Sinko, Jordan H Machlin, Gabrielle M Blevins, Marisa Leo, Ansen Tan, Bipasha Ray, Marilia Cascalho, Vasantha Padmanabhan, Ariella Shikanov

Journal: SCIENCE ADVANCES

PubMed ID: 41477848

Doi: 10.1126/sciadv.adx6348

Products & Services: Peptide Synthesis

DNA binding and dimerization of the SOG1 NAC domain are functionally linked with its ability to undergo liquid–liquid phase separation

Authors: Kim Mignon, Rani Van der Eecken, Margot Galle, Manon Demulder, Joris Van Lindt, Lieven De Veylder, Henri De Greve, Remy Loris

Journal: Nucleic Acids Research

PubMed ID: 41556342

Doi: 10.1093/nar/gkaf1522

Products & Services: Custom Vector Construction

Safeguarding genome integrity: Polo-like kinase Cdc5 and phosphatase Cdc14 orchestrate Topoisomerase II-mediated catenane resolution in mitosis

Authors: Lucia F Massari, Alice Finardi, Clara Visintin, Erika Calabrese, Ambra Dondi, Rosella Visintin

Journal: Nucleic Acids Research

PubMed ID: 41533572

Doi: 10.1093/nar/gkaf1509

Products & Services: Chemicals

The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction

Authors: Hongcheng Cheng, Yapeng Su, Xiaoli Pan, Yue Xu, Ermei Xie, Jing Du, Daniel G Chen, Xiaomeng Dai, Raphael Gottardo, Philip D Greenberg, Guideng Li

Journal: Nature

PubMed ID: 41535474

Doi: 10.1038/s41586-025-09926-8