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Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs

Authors: Yong Jiang, Anran Dai, Yuwei Huang, Hua Li, Jian Cui, Haochen Yang, Lu Si, Tao Jiao, Zhengxu Ren, Ziwei Zhang, Si Mou, Hengrui Zhu, Wenhui Guo, Qiang Huang, Yilin Li, Manman Xue, Jingwei Jiang, Fei Wang, Li Li, Qinying Zhong, Kun Wang, Baichuan Liu, Jinjiao Wang, Gaofeng Fan, Jun Guo, Liang Chen, Creg J Workman, Zhirong Shen, Yan Kong, Dario A A Vignali, Chenqi Xu, Haopeng Wang

Journal: Cell

PubMed ID: 40101708

Doi: 10.1016/j.cell.2025.02.014

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Structural basis for the substrate recognition and transport mechanism of the human y+LAT1-4F2hc transporter complex

Authors: Lu Dai, Qian Zeng, Ting Zhang, Yuanyuan Zhang, Yi Shi, Yaning Li, Kangtai Xu, Jing Huang, Zilong Wang, Qiang Zhou, Renhong Yan

Journal: SCIENCE ADVANCES

PubMed ID: 40106545

Doi: 10.1126/sciadv.adq0558

Products & Services: Protein and Antibody Isolation

Copper is essential for cyclin B1-mediated CDK1 activation

Authors: Jiaru Wang, Dian Yang, Hai-Fan Yu, Jing Jin, Yuzhe Nie, Sihua Zhang, Weiwei Ren, Zihan Ge, Zhuo Zhang, Xinghong Ma, Shaojun Dai, Guangchao Sui, Chun-Bo Teng

Journal: Nature Communications

PubMed ID: 40055333

Doi: 10.1038/s41467-025-57538-7

Products & Services: Protein and Antibody Isolation

Enzyme-activating B-cell receptors boost antigen presentation to pathogenic T cells in gluten-sensitive autoimmunity

Authors: Rasmus Iversen, Julie Elisabeth Heggelund, Saykat Das, Lene S Høydahl, Ludvig M Sollid

Journal: Nature Communications

PubMed ID: 40064932

Doi: 10.1038/s41467-025-57564-5

Products & Services: Antibody Services

Citrulline regulates macrophage metabolism and inflammation to counter aging in mice

Authors: Zhangdan Xie, Moubin Lin, Beizi Xing, Hongmiao Wang, Haosong Zhang, Zimu Cai, Xinyu Mei, Zheng-Jiang Zhu

Journal: SCIENCE ADVANCES

PubMed ID: 40053596

Doi: 10.1126/sciadv.ads4957

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Jumbo phage killer immune system targets early infection of nucleus-forming phages

Authors: Li Yuping, Linlin Guan, Isabelle Becher, Kira S Makarova, Xueli Cao, Surabhi Hareendranath, Jingwen Guan, Frank Stein, Siqi Yang, Arne Boergel, Karine Lapouge, Kim Remans, David Agard, Mikhail Savitski, Athanasios Typas, Eugene V Koonin, Yue Feng, Joseph Bondy-Denomy

Journal: Cell

PubMed ID: 40112800

Doi: 10.1016/j.cell.2025.02.016

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A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics

Authors: Marine Maupérin, Yuze Sun, Thomas Glandorf, Tabea Anne Oswald, Niklas Klatt, Burkhard Geil, Annick Mutero-Maeda, Isabelle Méan, Lionel Jond, Andreas Janshoff, Jie Yan, Sandra Citi

Journal: Nature Communications

PubMed ID: 40082413

Doi: 10.1038/s41467-025-57428-y

Nanoscale DNA tracing reveals the self-organization mechanism of mitotic chromosomes

Authors: Kai Sandvold Beckwith, Andreas Brunner, Natalia Rosalia Morero, Ralf Jungmann, Jan Ellenberg

Journal: Cell

PubMed ID: 39554202

Doi: 10.1101/2024.10.28.620625

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Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator

Authors: Demeng Sun, Xiang Li, Qingning Yuan, Yuanxia Wang, Pan Shi, Huanhuan Zhang, Tao Wang, Wenjing Sun, Shenglong Ling, Yuanchun Liu, Jinglin Lai, Wenqin Xie, Wanchao Yin, Lei Liu, H. Eric Xu, Changlin Tian

Journal: Cell Res

PubMed ID: 40118988

Doi: doi.org/10.1038/s41422-025-01095-7

Products & Services: Antibody Modification and Purification Services Protein and Antibody Isolation

A Functional 3D Biomimetic Osteon Accelerates Bone Regeneration

Authors: Chenxu Zhu, Zexi Li, Xubin Qiu, Baizhen Zhao, Huan Wang, Lijie Wang, Ming Zhuang, Jinbo Liu, Fengxuan Han, Bin Li

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202500603

Products & Services: Protein and Antibody Isolation