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FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

Authors: Ioanna A Rota, Adam E Handel, Stefano Maio, Fabian Klein, Fatima Dhalla, Mary E Deadman, Stanley Cheuk, Joseph A Newman, Yale S Michaels, Saulius Zuklys, Nicolas Prevot, Philip Hublitz, Philip D Charles, Athina Soragia Gkazi, Eleni Adamopoulou, Waseem Qasim, Edward Graham Davies, Imelda Hanson, Alistair T Pagnamenta, Carme Camps, Helene M Dreau, Andrea White, Kieran James, Roman Fischer, Opher Gileadi, Jenny C Taylor, Tudor Fulga, B Christoffer Lagerholm, Graham Anderson, Erdinc Sezgin, Georg A Holländer

Journal: Sci Adv

PubMed ID: 34860543

Doi: 10.1126/sciadv.abj9247

Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

Authors: Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde

Journal: Commun Biol

PubMed ID: 34853399

Doi: 10.1038/s42003-021-02866-9

Products & Services: Gene Synthesis

Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

Authors: Elif Karaaslan, Nesibe Selma Çetin, Merve Kalkan-Yazıcı, Sevde Hasanoğlu, Faruk Karakeçili, Aykut Özdarendeli, Ahmet Kalkan, Ali Osman Kılıç, Mehmet Ziya Doymaz

Journal: PLoS Negl Trop Dis

PubMed ID: 34851958

Doi: 10.1371/journal.pntd.0009973

Products & Services: Bacterial Expression

Humoral and cellular immune responses to the SARS-CoV-2 BNT162b2 vaccine among a cohort of solid organ transplant recipients and healthy controls

Authors: Ahmad Yanis, Zaid Haddadin, Andrew J Spieker, Danya Waqfi, Danielle A Rankin, Rana Talj, Lora Thomas, Kelly A Birdwell, Lauren Ezzell, Marcia Blair, Joan Eason, Rebekkah Varjabedian, Christian M Warren, Cynthia H Nochowicz, Eric C Olson, Joshua D Simmons, Sandra Yoder, Madeline Guy, Isaac Thomsen, James D Chappell, Spyros A Kalams, Natasha B Halasa

Journal: Transpl Infect Dis

PubMed ID: 34905653

Doi: 10.1111/tid.13772

Products & Services: Gene Synthesis

A de novo ACTB gene pathogenic variant in identical twins with phenotypic variation for hydrops and jejunal atresia

Authors: Kristina Sibbin, Patrick Yap, Denis Nyaga, Raoul Heller, Stephen Evans, Kate Strachan, Salam Alburaiky, Han M Alex Nguyen, Sylvie Hermann-Le Denmat, Austen R D Ganley, Justin M O'Sullivan, Frank H Bloomfield

Journal: Am J Med Genet A

PubMed ID: 34970864

Doi: 10.1002/ajmg.a.62631

Products & Services: Plasmid DNA Preparation

Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile

Authors: Daniel Rehling, Emma Rose Scaletti, Inna Rozman Grinberg, Daniel Lundin, Margareta Sahlin, Anders Hofer, Britt-Marie Sjöberg, Pål Stenmark

Journal: Biochemistry

PubMed ID: 34941255

Doi: 10.1021/acs.biochem.1c00503

Products & Services: PCR Cloning and Subcloning

A Highly Conserved Peptide Vaccine Candidate Activates Both Humoral and Cellular Immunity Against SARS-CoV-2 Variant Strains

Authors: Fengxia Gao, Jingjing Huang, Tingting Li, Chao Hu, Meiying Shen, Song Mu, Feiyang Luo, Shuyi Song, Yanan Hao, Wang Wang, Xiaojian Han, Chen Qian, Yingming Wang, Ruixin Wu, Luo Li, Shenglong Li, Aishun Jin

Journal: Front Immunol

PubMed ID: 34950151

Doi: 10.3389/fimmu.2021.789905

Products & Services: Protein and Antibody Isolation

Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model

Authors: Koji Terada, Kenta Kondo, Hirohito Ishigaki, Ayaka Nagashima, Hiroki Satooka, Seiji Nagano, Kyoko Masuda, Teruhisa Kawamura, Takako Hirata, Kazumasa Ogasawara, Yasushi Itoh, Hiroshi Kawamoto, Yasutoshi Agata

Journal: Mol Ther Oncolytics

PubMed ID: 35024435

Doi: 10.1016/j.omto.2021.12.003

Products & Services: Custom Vector Construction

Angiopoietin-2 silence alleviates lipopolysaccharide-induced inflammation, barrier dysfunction and endoplasmic reticulum stress of intestinal epithelial cells by blocking Notch signaling pathway

Authors: Liying Dai, Shuangshuang Jie, Shaohua Bi, Qing Qing, Jun Chen

Journal: Bioengineered

PubMed ID: 34565297

Doi: 10.1080/21655979.2021.1985341

Products & Services: Protein and Antibody Isolation

A clubroot pathogen effector targets cruciferous cysteine proteases to suppress plant immunity

Authors: Edel Pérez-López, Md Musharaf Hossain, Yangdou Wei, Christopher D Todd, Peta C Bonham-Smith

Journal: Virulence

PubMed ID: 34515618

Doi: 10.1080/21505594.2021.1968684

Products & Services: Mutant Libraries