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Modified pegRNAs mitigate scaffold-derived prime editing by-products

Authors: Panagiotis Antoniou, Louis Dacquay, Hanna Mårtensson, Katja Madeyski-Bengtson, Anna-Lena Loyd, Anna Shiriaeva, Euan Gordon, Salman Mustfa, George Thom, Pei-Pei Hsieh, Saša Šviković, Mike Firth, Nina Akrap, Marcello Maresca & Martin Peterka

Journal: Nature Communications

PubMed ID: 40204736

Doi: 10.1038/s41467-025-58653-1

Products & Services: Gene Synthesis

Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe

Authors: Pedro Ortega, Elodie Bournique, Junyi Li, Ambrocio Sanchez, Gisselle Santiago, Brooke R Harris, Josefine Striepen, John Maciejowski, Abby M Green, Rémi Buisson

Journal: SCIENCE ADVANCES

PubMed ID: 40238882

Doi: 10.1126/sciadv.adu0437

Products & Services: Gene Synthesis

Vibrio MARTX toxin binding of biantennary N-glycans at host cell surfaces

Authors: Jiexi Chen, Felix Goerdeler, Thapakorn Jaroentomeechai, Francisco X S Hernandez, Xiaozhong Wang, Henrik Clausen, Yoshiki Narimatsu, Karla J F Satchell

Journal: SCIENCE ADVANCES

PubMed ID: 40203092

Doi: 10.1126/sciadv.adt0063

Products & Services: Catalog Antibodies

Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1

Authors: Vincent Villeret

Journal: Nature Communications

PubMed ID: 40263353

Doi: 10.1038/s41467-025-59014-8

Products & Services: Gene Synthesis

Using Regular Porous Membrane-Based Blood−Brain Barrier Model to Screen Brain-Targeted Drugs with Nanochannel Electrochemistry

Authors: Yafeng Wu，Zixuan Chen，Fengxiang Chen，Juan Su，Jianyu Han，Songqin Liu

Journal: Anal Chem

PubMed ID: 40183921

Doi: 10.1021/acs.analchem.5c00365

Products & Services: Peptide Synthesis

Molecular mechanisms of the viral encoded chaperone 100K in capsid folding and assembly of adenovirus

Authors: Haining Li , Luyuan Shao , Zhe Liu , Qi Liu , Ye Xiang

Journal: Nat Commun

PubMed ID: 40301360

Doi: 10.1038/s41467-025-59301-4

Products & Services: Protein and Antibody Isolation

Molecular determinants for the association of human hormone-sensitive lipase with lipid droplets

Authors: Han Peng, Qikui Xu, Ting Zhang, Jiakai Zhu, Jinheng Pan, Xiaoyu Guan, Shan Feng, Jianping Wu, Qi Hu

Journal: nature COMMUNICATION

PubMed ID: 40221426

Doi: 10.1038/s41467-025-58887-z

Products & Services: Protein and Antibody Isolation

Self-oxygenating nanoplatform integrating CRISPR/Cas9 gene editing and immune activation for highly efficient photodynamic therapy

Authors: Shi-Cheng Tian, Xun-Huan Song, Ke-Ke Feng, Cheng-Lei Li, Yi-Fan Tu, Yong-Shan Hu, Jing-Wei Shao

Journal: Journal of colloid and interface science

PubMed ID: 40262200

Doi: 10.1016/j.jcis.2025.137632

Products & Services: Synthetic Guide RNA

Intranasal influenza virus-vectored vaccine offers protection against clade 2.3.4.4b H5N1 infection in small animal models

Authors: Ying Liu, Shaofeng Deng, Shuang Ren, Rachel Chun-Yee Tam, Siwen Liu, Anna Jinxia Zhang, Kelvin Kai-Wang To, Kwok-Yung Yuen, Honglin Chen & Pui Wang

Journal: Nature Communications

PubMed ID: 40169649

Doi: 10.1038/s41467-025-58504-z

Products & Services: Peptide Synthesis

True length of diverse capped RNA sequencing (TLDR-seq): 5′–3′-end sequencing of capped RNAs regardless of 3′-end status

Authors: Jamie Auxillos, Arnaud Stigliani, Christian Skov Vaagensø, William Garland, Adnan Muhammed Niazi, Eivind Valen, Torben Heick Jensen, Albin Sandelin

Journal: Nucleic Acids Research

PubMed ID: 40183637

Doi: 10.1093/nar/gkaf240

Products & Services: Molecular Biology Reagents