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Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern

Authors: Jeroen Pollet, Ulrich Strych, Wen-Hsiang Chen, Leroy Versteeg, Brian Keegan, Bin Zhan, Junfei Wei, Zhuyun Liu, Jungsoon Lee, Rakhi Kundu, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar, Syamala Rani Thimmiraju, Brianna Lopez, Portia M Gillespie, Shannon Ronca, Jason T Kimata, Martin Reers, Vikram Paradkar, Peter Hotez, Maria Elena Bottazzi

Journal: biorxiv

PubMed ID: 34268512

Doi: 10.1101/2021.07.06.451353

Products & Services: Gene Fragments

Glutathione binding to the plant Atm3 transporter and implications for the conformational coupling of ABC transporters

Authors: Chengcheng Fan, Douglas C Rees

Journal: Elife

PubMed ID: 35333177

Doi: 10.7554/eLife.76140

Products & Services: Mutagenesis Services

Structural Basis for Human Receptor Recognition by SARS-CoV-2 Omicron Variant BA1

Authors: Qibin Geng, Ke Shi, Gang Ye, Wei Zhang, Hideki Aihara, Fang Li

Journal: J Virol

PubMed ID: 35343765

Doi: 10.1128/jvi.00249-22

Products & Services: Gene Synthesis

Mouse Adenovirus Type 1 E4orf6 Induces PKR Degradation

Authors: Berto Tejera-Hernández, Danielle E Goodman, Juan M Nevarez, Katherine R Spindler

Journal: J Virol

PubMed ID: 35285681

Doi: 10.1128/jvi.02063-21

Products & Services: Plasmid DNA Preparation

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

Authors: Cheng Li, Wuqiang Zhan, Zhenlin Yang, Chao Tu, Gaowei Hu, Xiang Zhang, Wenping Song, Shujuan Du, Yuanfei Zhu, Keke Huang, Yu Kong, Meng Zhang, Qiyu Mao, Xiaodan Gu, Yi Zhang, Youhua Xie, Qiang Deng, Yuanlin Song, Zhenguo Chen, Lu Lu, Shibo Jiang, Yanling Wu, Lei Sun, Tianlei Ying

Journal: Cell

PubMed ID: 35344711

Doi: 10.1016/j.cell.2022.03.009

Products & Services: PCR Cloning and Subcloning

A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder

Authors: Margit Kaldmäe, Thibault Vosselman, Xueying Zhong, Dilraj Lama, Gefei Chen, Mihkel Saluri, Nina Kronqvist, Jia Wei Siau, Aik Seng Ng, Farid J Ghadessy, Pierre Sabatier, Borivoj Vojtesek, Médoune Sarr, Cagla Sahin, Nicklas Österlund, Leopold L Ilag, Venla A Väänänen, Saikiran Sedimbi, Marie Arsenian-Henriksson, Roman A Zubarev, Lennart Nilsson, Philip J B Koeck, Anna Rising, Axel Abelein, Nicolas Fritz, Jan Johansson, David P Lane, Michael Landreh

Journal: Structure

PubMed ID: 35290795

Doi: 10.1016/j.str.2022.02.013

Products & Services: Protein and Antibody Isolation

Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations

Authors: Zheng Fang Yang, Pankaj Panwar, Ciaran R McFarlane, Wietske E Tuinte, Marta Campiglio, Filip Van Petegem

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35238659

Doi: 10.1073/pnas.2120416119

Products & Services: Mammalian Expression

Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities

Authors: Suhail Khoja, Jenna Lambert, Matthew Nitzahn, Adam Eliav, YuChen Zhang, Mikayla Tamboline, Colleen T Le, Eram Nasser, Yunfeng Li, Puja Patel, Irina Zhuravka, Lindsay M Lueptow, Ilona Tkachyova, Shili Xu, Itzhak Nissim, Andreas Schulze, Gerald S Lipshutz

Journal: Mol Ther Methods Clin Dev

PubMed ID: 35505663

Doi: 10.1016/j.omtm.2022.03.015

Products & Services: Custom Vector Construction

Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules

Authors: Hui Jin, Kazuki Kishida, Noriko Arase, Sumiko Matsuoka, Wataru Nakai, Masako Kohyama, Tadahiro Suenaga, Ken Yamamoto, Takehiko Sasazuki, Hisashi Arase

Journal: Sci Adv

PubMed ID: 35245125

Doi: 10.1126/sciadv.abj9867

Products & Services: Peptide Synthesis

The interaction of dengue virus capsid protein with negatively charged interfaces drives the in vitro assembly of nucleocapsid-like particles

Authors: Nathane C Mebus-Antunes, Wellington S Ferreira, Glauce M Barbosa, Thais C Neves-Martins, Gilberto Weissmuller, Fabio C L Almeida, Andrea T Da Poian

Journal: PLoS ONE

PubMed ID: 35231063

Doi: 10.1371/journal.pone.0264643

Products & Services: Protein and Antibody Isolation