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Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design
Authors: rsula L pez-Garc a; Jan Vietor; Julian A. Marschner; Jan Heering; Vasily Morozov; Thomas Wein; Daniel Merk
Journal: Communications Chemistry
PubMed ID: 40399628
Doi: 10.1038/s42004-025-01553-8
Products & Services: Plasmid DNA Preparation   
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo
Authors: Nian E. Zhou; Su Tang; Xuelin Bian; Maloy K. Parai; Inna V. Krieger; Armando Flores; Pradeep K. Jaiswal; Radha Bam; Jeremy L. Wood; Zhe Shi; Laura J. Stevens; Trevor Scobey; Meghan V. Diefenbacher; Fernando R. Moreira; Thomas J. Baric; Arjun Acharya; Joonyoung Shin; Manish M. Rathi; Karen C. Wolff; Laura Riva; Malina A. Bakowski; Case W. McNamara; Nicholas J. Catanzaro; Rachel L. Graham; David C. Schultz; Sara Cherry; Yoshihiro Kawaoka; Peter J. Halfmann; Ralph S. Baric; Mark R. Denison; Timothy P. Sheahan; James C. Sacchettini
Journal: Cell Reports
PubMed ID: 39504242
Doi: 10.1016/j.celrep.2024.114929
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo
Authors: Nian E. Zhou; Su Tang; Xuelin Bian; Maloy K. Parai; Inna V. Krieger; Armando Flores; Pradeep K. Jaiswal; Radha Bam; Jeremy L. Wood; Zhe Shi; Laura J. Stevens; Trevor Scobey; Meghan V. Diefenbacher; Fernando R. Moreira; Thomas J. Baric; Arjun Acharya; Joonyoung Shin; Manish M. Rathi; Karen C. Wolff; Laura Riva; Malina A. Bakowski; Case W. McNamara; Nicholas J. Catanzaro; Rachel L. Graham; David C. Schultz; Sara Cherry; Yoshihiro Kawaoka; Peter J. Halfmann; Ralph S. Baric; Mark R. Denison; Timothy P. Sheahan; James C. Sacchettini
Journal: Cell Reports
PubMed ID: 39504242
Doi: 10.1016/j.celrep.2024.114929
Peritumoural adipose tissue promotes ferroptosis resistance by 3-hydroxykynurenine-mediated suppression of ferritinophagy
Authors: Yan-Yu Zhang, Yi Han, Yue-Tao Tan, Yun-Xin Lu, Meng-Yao Ma, Yong-Qiang Zheng, Hao-Jie Chen, Hai-Yan Fu, Hai-Yu Mo, Qi-Nian Wu, Xiao-Jing Luo, Kun Liao, Wen-Qi Chen, Zhao-Lei Zeng, Hai-Long Piao, Hong-Li Du, Jun-Zhong Lin, Tian Tian, Rui-Hua Xu, Huai-Qiang Ju
Journal: Nature Cell Biology
PubMed ID: 41813885
Doi: 10.1038/s41556-026-01907-x
Products & Services: Protein and Antibody Isolation   
Engineered outer membrane vesicles enhance solid tumour CAR-T cell therapy
Authors: Xianjun Li, Xuehan Li, Jiaqi Shi, Yingjing Li, Hanyu Zhang, Tianjun Chen, Hui Pang, Shuyuan Zhang, Shengnan Luo, Fengyi Liu, Shuang Li, Chujie Ding, Linlin Sun, Fan Xing, Tongsen Zheng
Journal: Nature biomedical engineering
PubMed ID: 41501251
Doi: 10.1038/s41551-025-01575-6
Products & Services: Protein and Antibody Isolation   
Microvascular remodeling strategy for skin rejuvenation through microenvironmental reprogramming and appendage restoration
Authors: Jialiang Zhou, Shengjie Jiang, Liyun Wang, Tingting Dong, Li Yu, Haiyan Li, Zhen Gao, Jianyong Wu, Kaili Lin
Journal: Biomaterials
PubMed ID: 42107134
Doi: 10.1016/j.biomaterials.2026.124249
Products & Services: Protein Electrophoresis and Western   
Quadruple pegRNA enables programmable and efficient large genomic insertion
Authors: Ya-Jing Shi, Zi-Yi Ding, Ying Wu, Zhou He, Yi-Zhou Zhang, Yu-Lu Zhang, Yu-Ming Zhang, Xiang-Rui Huang, Hao Yin, Ying Zhang
Journal: Nature
PubMed ID: 42020736
Doi: 10.1038/s41586-026-10395-w
Products & Services: Cell Isolation   
Modulation of the pharmacokinetics of soluble ACE2 decoy receptors through glycosylation
Authors: Savanna Skeeters; Kamal Bagale; Galina Stepanyuk; David Thieker; Aaron Aguhob; Kui K. Chan; Benjamin Dutzar; Sergei Shalygin; Asif Shajahan; Xu Yang; Paul A. DaRosa; Emily Frazier; Maximilian M. Sauer; Lisa Bogatzki; Kelly A. Byrnes-Blake; Yifan Song; Parastoo Azadi; Eric Tarcha; Lianghui Zhang; Erik Procko
Journal: Molecular therapy. Methods & clinical development
PubMed ID: 39185275
Doi: 10.1016/j.omtm.2024.101301
Products & Services: Protein and Antibody Reagents   
Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design
Authors: rsula L pez-Garc a; Jan Vietor; Julian A. Marschner; Jan Heering; Vasily Morozov; Thomas Wein; Daniel Merk
Journal: Communications Chemistry
PubMed ID: 40399628
Doi: 10.1038/s42004-025-01553-8
Products & Services: Plasmid DNA Preparation   
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo
Authors: Nian E. Zhou; Su Tang; Xuelin Bian; Maloy K. Parai; Inna V. Krieger; Armando Flores; Pradeep K. Jaiswal; Radha Bam; Jeremy L. Wood; Zhe Shi; Laura J. Stevens; Trevor Scobey; Meghan V. Diefenbacher; Fernando R. Moreira; Thomas J. Baric; Arjun Acharya; Joonyoung Shin; Manish M. Rathi; Karen C. Wolff; Laura Riva; Malina A. Bakowski; Case W. McNamara; Nicholas J. Catanzaro; Rachel L. Graham; David C. Schultz; Sara Cherry; Yoshihiro Kawaoka; Peter J. Halfmann; Ralph S. Baric; Mark R. Denison; Timothy P. Sheahan; James C. Sacchettini
Journal: Cell Reports
PubMed ID: 39504242
Doi: 10.1016/j.celrep.2024.114929
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