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Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol

Authors: Rodrigo Ochoa, Victoria Alves Santos Lunardelli, Daniela Santoro Rosa, Alessandro Laio, Pilar Cossio

Journal: Front Immunol

PubMed ID: 35572587

Doi: 10.3389/fimmu.2022.862851

Products & Services: Peptide Synthesis

A conserved module regulates receptor kinase signalling in immunity and development

Authors: Thomas A DeFalco, Pauline Anne, Sean R James, Andrew C Willoughby, Florian Schwanke, Oliver Johanndrees, Yasmine Genolet, Paul Derbyshire, Qian Wang, Surbhi Rana, Anne-Marie Pullen, Frank L H Menke, Cyril Zipfel, Christian S Hardtke, Zachary L Nimchuk

Journal: Nat Plants

PubMed ID: 35422079

Doi: 10.1038/s41477-022-01134-w

Products & Services: Catalog Peptides

Gain-of-function and loss-of-function GABRB3 variants lead to distinct clinical phenotypes in patients with developmental and epileptic encephalopathies

Authors: Nathan L Absalom, Vivian W Y Liao, Katrine M H Johannesen, Elena Gardella, Julia Jacobs, Gaetan Lesca, Zeynep Gokce-Samar, Alexis Arzimanoglou, Shimriet Zeidler, Pasquale Striano, Pierre Meyer, Ira Benkel-Herrenbrueck, Inger-Lise Mero, Jutta Rummel, Mary Chebib, Rikke S Møller, Philip K Ahring

Journal: Nat Commun

PubMed ID: 35383156

Doi: 10.1038/s41467-022-29280-x

Products & Services: PCR Cloning and Subcloning

A Single-Domain TCR-like Antibody Selective for the Qa-1/Qdm Peptide Complex Enhances Tumoricidal Activity of NK Cells via Blocking the NKG2A Immune Checkpoint

Authors: Soroush Ghaffari, Katherine Upchurch-Ange, Susanne Gimlin, Trivendra Tripathi, Marjolein Sluijter, Jim Middelburg, Thorbald van Hall, Jon Weidanz

Journal: J Immunol

PubMed ID: 35418467

Doi: 10.4049/jimmunol.2100790

Products & Services: Protein and Antibody Isolation

Structural insight into UV-B-activated UVR8 bound to COP1

Authors: Yidong Wang, Lixia Wang, Zeyuan Guan, Hongfei Chang, Ling Ma, Cuicui Shen, Liang Qiu, Junjie Yan, Delin Zhang, Jian Li, Xing Wang Deng, Ping Yin

Journal: Sci Adv

PubMed ID: 35442727

Doi: 10.1126/sciadv.abn3337

Products & Services: Protein and Antibody Isolation

Humoral immunity against SARS-CoV-2 variants including omicron in solid organ transplant recipients after three doses of a COVID-19 mRNA vaccine

Authors: Kapil K Saharia, Jennifer S Husson, Silke V Niederhaus, Thierry Iraguha, Stephanie V Avila, Youngchae J Yoo, Nancy M Hardy, Xiaoxuan Fan, Destiny Omili, Alice Crane, Amber Carrier, Wen Y Xie, Erica Vander Mause, Kim Hankey, Sherri Bauman, Patricia Lesho, Heather D Mannuel, Ashish Ahuja, Minu Mathew, James Avruch, John Baddley, Olga Goloubeva, Kirti Shetty, Saurabh Dahiya, Aaron P Rapoport, Tim Luetkens, Djordje Atanackovic

Journal: Clin Transl Immunology

PubMed ID: 35505864

Doi: 10.1002/cti2.1391

Products & Services: Catalog Peptides

Tripartite motif containing 63, regulated by E26 transformation specific variant 4, facilitates the thyroid carcinoma progression and the AKT, p38, and ERK signaling pathways

Authors: Jingni He, Ying Zhang, Baiyu Yao, Lidong Wang, Zhong Tian

Journal: Mol Cell Endocrinol

PubMed ID: 35390449

Doi: 10.1016/j.mce.2022.111639

Products & Services: Gene Synthesis

Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu supplants entropically favoured Zn to form Cu clusters under physiological conditions

Authors: Matthew R Mehlenbacher, Rahma Elsiesy, Rabina Lakha, Rhiza Lyne E Villones, Marina Orman, Christina L Vizcarra, Gabriele Meloni, Dean E Wilcox, Rachel N Austin

Journal: Chem Sci

PubMed ID: 35655557

Doi: 10.1039/d2sc00676f

Products & Services: Codon Optimization

Peptide of Infective Larval Extract That Harnesses Growth of Human Hepatoma Cells

Authors: Pichet Ruenchit, Onrapak Reamtong, Ladawan Khowawisetsut, Poom Adisakwattana, Monrat Chulanetra, Kasem Kulkeaw, Wanpen Chaicumpa

Journal: Front Cell Infect Microbiol

PubMed ID: 35558100

Doi: 10.3389/fcimb.2022.882608

Products & Services: Peptide Synthesis

Melatonin Mediated Differential Regulation of Drought Tolerance in Sensitive and Tolerant Varieties of Upland Cotton (

Authors: Laha Supriya, Pullaiahgari Durgeshwar, Mehanathan Muthamilarasan, Gudipalli Padmaja

Journal: Front Plant Sci

PubMed ID: 35444676

Doi: 10.3389/fpls.2022.821353

Products & Services: Protein and Antibody Isolation