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A clubroot pathogen effector targets cruciferous cysteine proteases to suppress plant immunity

Authors: Edel Pérez-López, Md Musharaf Hossain, Yangdou Wei, Christopher D Todd, Peta C Bonham-Smith

Journal: Virulence

PubMed ID: 34515618

Doi: 10.1080/21505594.2021.1968684

Products & Services: Mutant Libraries

Interaction of huntingtin (HTT) with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity

Authors: Tamara Ratovitski, Mali Jiang, Robert N O'Meally, Priyanka Rauniyar, Ekaterine Chighladze, Anikó Faragó, Siddhi V Kamath, Jing Jin, Alexey V Shevelkin, Robert N Cole, Christopher A Ross

Journal: Hum Mol Genet

PubMed ID: 34888656

Doi: 10.1093/hmg/ddab351

Products & Services: Gene Synthesis

TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

Authors: Parminder Kaur, Ryan Barnes, Hai Pan, Ariana C Detwiler, Ming Liu, Chelsea Mahn, Jonathan Hall, Zach Messenger, Changjiang You, Jacob Piehler, Robert C Smart, Robert Riehn, Patricia L Opresko, Hong Wang

Journal: Nucleic Acids Res

PubMed ID: 34883513

Doi: 10.1093/nar/gkab1142

Products & Services: Protein and Antibody Isolation

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

Authors: K Y Chen, T Krischuns, L Ortega Varga, E Harigua-Souiai, S Paisant, A Zettor, J Chiaravalli, D Courtney, A O'Brien, S C Baker, C Isel, F Agou, Y Jacob, A Blondel, N Naffakh

Journal: biorxiv

PubMed ID: 34981051

Doi: 10.1101/2021.12.18.473303

Products & Services: PCR Cloning and Subcloning

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Authors: Sandile Cele, Laurelle Jackson, David S Khoury, Khadija Khan, Thandeka Moyo-Gwete, Houriiyah Tegally, James Emmanuel San, Deborah Cromer, Cathrine Scheepers, Daniel G Amoako, Farina Karim, Mallory Bernstein, Gila Lustig, Derseree Archary, Muneerah Smith, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Shi-Hsia Hwa, Jennifer Giandhari, Jonathan M Blackburn, Bernadett I Gosnell, Salim S Abdool Karim, Willem Hanekom, Anne von Gottberg, Jinal N Bhiman, Richard J Lessells, Mahomed-Yunus S Moosa, Miles P Davenport, Tulio de Oliveira, Penny L Moore, Alex Sigal

Journal: Nature

PubMed ID: 35016196

Doi: 10.1038/s41586-021-04387-1

Products & Services: Monoclonal Antibody Services

Cepharanthine Blocks Presentation of Thyroid and Islet Peptides in a Novel Humanized Autoimmune Diabetes and Thyroiditis Mouse Model

Authors: Cheuk Wun Li, Roman Osman, Francesca Menconi, Larissa C Faustino, Kookjoo Kim, Oliver B Clarke, Hanxi Hou, Yaron Tomer

Journal: Front Immunol

PubMed ID: 34987519

Doi: 10.3389/fimmu.2021.796552

Products & Services: Peptide Synthesis

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs

Authors: Lu Xu, Bo Chen, Hannes Schihada, Shane C Wright, Ainoleena Turku, Yiran Wu, Gye-Won Han, Maria Kowalski-Jahn, Pawel Kozielewicz, Carl-Fredrik Bowin, Xianjun Zhang, Chao Li, Michel Bouvier, Gunnar Schulte, Fei Xu

Journal: Cell Research

PubMed ID: 34239071

Doi: 10.1038/s41422-021-00525-6

Products & Services: Protein and Antibody Isolation SDS-PAGE胶

Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

Authors: Martin Marek, Elizabeth Ramos-Morales, Gisele F A Picchi-Constante, Theresa Bayer, Carina Norström, Daniel Herp, Policarpo A Sales-Junior, Eloise P Guerra-Slompo, Kristin Hausmann, Alokta Chakrabarti, Tajith B Shaik, Annika Merz, Edouard Troesch, Karin Schmidtkunz, Samuel Goldenberg, Raymond J Pierce, Marina M Mourão, Manfred Jung, Johan Schultz, Wolfgang Sippl, Nilson I T Zanchin, Christophe Romier

Journal: Cell Rep

PubMed ID: 34936867

Doi: 10.1016/j.celrep.2021.110129

Products & Services: Plasmid DNA Preparation

Multiple RNA virus matrix proteins interact with SLD5 to manipulate host cell cycle

Authors: Li Zhu, Xinyu Li, Henan Xu, Lifeng Fu, George Fu Gao, Wenjun Liu, Linqing Zhao, Xiaojun Wang, Wei Jiang, Min Fang

Journal: J Gen Virol

PubMed ID: 34882534

Doi: 10.1099/jgv.0.001697

Products & Services: Polyclonal Antibody Services

In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei

Authors: Abhishek Dey, Anais Monroy-Eklund, Kaitlin Klotz, Arpita Saha, Justin Davis, Bibo Li, Alain Laederach, Kausik Chakrabarti

Journal: Nucleic Acids Res

PubMed ID: 34850114

Doi: 10.1093/nar/gkab1042

Products & Services: Catalog Antibodies