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The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost

Authors: Paolo Mesén-Ramírez, Bärbel Bergmann, Mourad Elhabiri, Lei Zhu, Heidrun von Thien, Carolina Castro-Peña, Tim-Wolf Gilberger, Elisabeth Davioud-Charvet, Zbynek Bozdech, Anna Bachmann, Tobias Spielmann

Journal: Cell Host Microbe

PubMed ID: 34863371

Doi: 10.1016/j.chom.2021.11.002

Products & Services: Stable Cell Lines

The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target

Authors: Gergely Rona, Andras Zeke, Bearach Miwatani-Minter, Maren de Vries, Ramanjit Kaur, Austin Schinlever, Sheena Faye Garcia, Hailey V Goldberg, Hui Wang, Thomas R Hinds, Fabrice Bailly, Ning Zheng, Philippe Cotelle, Didier Desmaële, Nathaniel R Landau, Meike Dittmann, Michele Pagano

Journal: Cell Death Differ

PubMed ID: 34862481

Doi: 10.1038/s41418-021-00900-1

Products & Services: Codon Optimization

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

Authors: Ioanna A Rota, Adam E Handel, Stefano Maio, Fabian Klein, Fatima Dhalla, Mary E Deadman, Stanley Cheuk, Joseph A Newman, Yale S Michaels, Saulius Zuklys, Nicolas Prevot, Philip Hublitz, Philip D Charles, Athina Soragia Gkazi, Eleni Adamopoulou, Waseem Qasim, Edward Graham Davies, Imelda Hanson, Alistair T Pagnamenta, Carme Camps, Helene M Dreau, Andrea White, Kieran James, Roman Fischer, Opher Gileadi, Jenny C Taylor, Tudor Fulga, B Christoffer Lagerholm, Graham Anderson, Erdinc Sezgin, Georg A Holländer

Journal: Sci Adv

PubMed ID: 34860543

Doi: 10.1126/sciadv.abj9247

Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

Authors: Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde

Journal: Commun Biol

PubMed ID: 34853399

Doi: 10.1038/s42003-021-02866-9

Products & Services: Gene Synthesis

Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

Authors: Elif Karaaslan, Nesibe Selma Çetin, Merve Kalkan-Yazıcı, Sevde Hasanoğlu, Faruk Karakeçili, Aykut Özdarendeli, Ahmet Kalkan, Ali Osman Kılıç, Mehmet Ziya Doymaz

Journal: PLoS Negl Trop Dis

PubMed ID: 34851958

Doi: 10.1371/journal.pntd.0009973

Products & Services: Bacterial Expression

Dynamic Distribution of HIG2A between the Mitochondria and the Nucleus in Response to Hypoxia and Oxidative Stress

Authors: Celia Salazar, Miriam Barros, Alvaro A Elorza, Lina María Ruiz

Journal: Int J Mol Sci

PubMed ID: 35008815

Doi: 10.3390/ijms23010389

Products & Services: Plasmid DNA Preparation

Glycoside Hydrolase family 30 harbors fungal subfamilies with distinct polysaccharide specificities

Authors: Xinxin Li, Dimitrios Kouzounis, Mirjam A Kabel, Ronald P de Vries, Adiphol Dilokpimol