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Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

Authors: Andrea Pawellek; Ursula Ryder; Triin Tammsalu; Lewis J King; Helmi Kreinin; Tony Ly; Ronald T Hay; Richard C Hartley; Angus I Lamond

Journal: Elife

PubMed ID: 28884683

Doi: 10.7554/eLife.27402

Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug resistant fungi

Authors: Xuefei Chen; H. Diessel Duan; Michael J. Hoy; Kalinka Koteva; Michaela Spitzer; Allison K. Guitor; Emily Puumala; Aline A. Fiebig; Guanggan Hu; Bonnie Yiu; Sommer Chou; Zhuyun Bian; Yeseul Choi; Amelia Bing Ya Guo; Wenliang Wang; Sheng Sun; Nicole Robbins; Anna Floyd Averette; Michael A. Cook; Ray Truant; Lesley T. MacNeil; Eric D. Brown; James W. Kronstad; Brian K. Coombes; Leah E. Cowen; Joseph Heitman; Huilin Li; Gerard D. Wright

Journal: Cell

PubMed ID: 41478284

Doi: 10.1016/j.cell.2025.11.036

Products & Services: Protein and Antibody Isolation

A model for drug transport across two membranes of Gram-negative bacteria by an MFS tripartite assembly

Authors: Zhaojun Zhong; Tuerxunjiang Maimaiti; Matthew L. Jackson; Rui Dong; Xueyan Gao; Qing Ouyang; Wenqian Wang; Jinliang Guo; Shangrong Li; Wenyu Shang; Huajun Liu; Hongnian Jiang; Shuo Zhang; Ulrich Zachariae; Ben F. Luisi; Yanjie Chao; Dijun Du

Journal: Nature Communications

PubMed ID: 41839863

Doi: 10.1038/s41467-026-70500-5

Products & Services: Protein and Antibody Isolation

Rgs16 promotes antitumor CD8 T cell exhaustion

Authors: Nina Weisshaar, Jingxia Wu, Yanan Ming, Alaa Madi, Agnes Hotz-Wagenblatt, Sicong Ma, Alessa Mieg, Marvin Hering, Ferdinand Zettl, Kerstin Mohr, Tilo Schlimbach, Nora Ten Bosch, Franziska Hertel, Lisann Müller, Hannah Byren, Mona Wang, Helena Borgers, Mareike Munz, Lukas Schmitt, Franciscus van der Hoeven, Ulrich Kloz, Rafael Carretero, Nikolai Schleußner, Rene-Filip Jackstadt, Ilse Hofmann, Guoliang Cui

Journal: Sci Immunol

PubMed ID: 35622904

Doi: 10.1126/sciimmunol.abh1873

Products & Services: Catalog Peptides

Agrobacterium expressing a type III secretion system delivers Pseudomonas effectors into plant cells to enhance transformation

Authors: Vidhyavathi Raman, Clemencia M Rojas, Balaji Vasudevan, Kevin Dunning, Jaydeep Kolape, Sunhee Oh, Jianfei Yun, Lishan Yang, Guangming Li, Bikram D Pant, Qingzhen Jiang, Kirankumar S Mysore

Journal: Nat Commun

PubMed ID: 35546550

Doi: 10.1038/s41467-022-30180-3

Products & Services: Bacterial Expression

The tRNA discriminator base defines the mutual orthogonality of two distinct pyrrolysyl-tRNA synthetase/tRNAPyl pairs in the same organism

Authors: Haolin Zhang, Xuemei Gong, Qianqian Zhao, Takahito Mukai, Oscar Vargas-Rodriguez, Huiming Zhang, Yuxing Zhang, Paul Wassel, Kazuaki Amikura, Julie Maupin-Furlow, Yan Ren, Xun Xu, Yuri I Wolf, Kira S Makarova, Eugene V Koonin, Yue Shen, Dieter Söll, Xian Fu

Journal: Nucleic Acids Res

PubMed ID: 35466371

Doi: 10.1093/nar/gkac271

Products & Services: Protein and Antibody Isolation

BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia

Authors: Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraju

Journal: Mol Neurodegener

PubMed ID: 35526014

Doi: 10.1186/s13024-022-00535-x

Products & Services: Plasmid DNA Preparation

Plantaricin A, Derived from Lactiplantibacillus plantarum, Reduces the Intrinsic Resistance of Gram-Negative Bacteria to Hydrophobic Antibiotics

Authors: Fanqiang Meng, Yanan Liu, Ting Nie, Chao Tang, Fengxia Lyu, Xiaomei Bie, Yingjian Lu, Mingwen Zhao, Zhaoxin Lu

Journal: Appl Environ Microbiol

PubMed ID: 35499329

Doi: 10.1128/aem.00371-22

Products & Services: Peptide Synthesis

Preclinical Assessment of IgY Antibodies Against Recombinant SARS-CoV-2 RBD Protein for Prophylaxis and Post-Infection Treatment of COVID-19

Authors: Andres Agurto-Arteaga, Astrid Poma-Acevedo, Dora Rios-Matos, Ricardo Choque-Guevara, Ricardo Montesinos-Millán, Ángela Montalván, Gisela Isasi-Rivas, Yudith Cauna-Orocollo, María de Grecia Cauti-Mendoza, Norma Pérez-Martínez, Kristel Gutierrez-Manchay, Ingrid Ramirez-Ortiz, Dennis Núñez-Fernández, Mario I Salguedo-Bohorquez, Stefany Quiñones-Garcia, Manolo Fernández Díaz, Luis A Guevara Sarmiento, Mirko Zimic

Journal: Front Immunol

PubMed ID: 35664008

Doi: 10.3389/fimmu.2022.881604

Products & Services: Catalog Antibodies

Assessing four subdomain-specific affinity resins' capability to separate half-antibody from intact bispecific antibody

Authors: Wei Chen, Ting Zhang, Yan Wan, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 35661701

Doi: 10.1016/j.pep.2022.106124

Products & Services: Protein Electrophoresis and Western