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Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/b-catenin signaling

Authors: Xiaowen Chen , Huishi Tan , Jie Xu , Yuan Tian , Qian Yuan , Yangyang Zuo , Qiyan Chen , Xue Hong , Haiyan Fu , Fan Fan Hou , Lili Zhou , Youhua Liu

Journal: Kidney Int

PubMed ID: 35644285

Doi: 10.1016/j.kint.2022.04.028

Products & Services: Peptide Synthesis

Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation

Authors: Antonio Sorrentino, Ayse Nur Menevse, Tillmann Michels, Valentina Volpin, Franziska Christine Durst, Julian Sax, Maria Xydia, Abir Hussein, Slava Stamova, Steffen Spoerl, Nicole Heuschneider, Jasmin Muehlbauer, Katharina Marlene Jeltsch, Anchana Rathinasamy, Melanie Werner-Klein, Marco Breinig, Damian Mikietyn, Christian Kohler, Isabel Poschke, Sabrina Purr, Olivia Reidell, Catarina Martins Freire, Rienk Offringa, Claudia Gebhard, Rainer Spang, Michael Rehli, Michael Boutros, Christian Schmidl, Nisit Khandelwal, Philipp Beckhove

Journal: J Immunother Cancer

PubMed ID: 35606086

Doi: 10.1136/jitc-2021-004258

Products & Services: Plasmid DNA Preparation

SARS-CoV-2-mRNA Booster Vaccination Reverses Non-Responsiveness and Early Antibody Waning in Immunocompromised Patients - A Phase Four Study Comparing Immune Responses in Patients With Solid Cancers, Multiple Myeloma and Inflammatory Bowel Disease

Authors: Angelika Wagner, Erika Garner-Spitzer, Anna-Margarita Schötta, Maria Orola, Andrea Wessely, Ines Zwazl, Anna Ohradanova-Repic, Lukas Weseslindtner, Gabor Tajti, Laura Gebetsberger, Bernhard Kratzer, Elena Tomosel, Maximilian Kutschera, Selma Tobudic, Winfried F Pickl, Michael Kundi, Hannes Stockinger, Gottfried Novacek, Walter Reinisch, Christoph Zielinski, Ursula Wiedermann

Journal: Front Immunol

PubMed ID: 35634285

Doi: 10.3389/fimmu.2022.889138

Disordered Regions Flanking the Binding Interface Modulate Affinity between CBP and NCOA

Authors: Elin Karlsson, Jan Schnatwinkel, Cristina Paissoni, Eva Andersson, Christian Herrmann, Carlo Camilloni, Per Jemth

Journal: J Mol Biol

PubMed ID: 35605677

Doi: 10.1016/j.jmb.2022.167643

Products & Services: Plasmid DNA Preparation

A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases

Authors: Inna Rozman Grinberg, Markel Martínez-Carranza, Ornella Bimai, Ghada Nouaïria, Saher Shahid, Daniel Lundin, Derek T Logan, Britt-Marie Sjöberg, Pål Stenmark

Journal: Nat Commun

PubMed ID: 35577776

Doi: 10.1038/s41467-022-30328-1

Products & Services: Custom DNA/RNA Oligos

Durable immunogenicity, adaptation to emerging variants, and low-dose efficacy of an AAV-based COVID-19 vaccine platform in macaques

Authors: Nerea Zabaleta, Urja Bhatt, Cécile Hérate, Pauline Maisonnasse, Julio Sanmiguel, Cheikh Diop, Sofia Castore, Reynette Estelien, Dan Li, Nathalie Dereuddre-Bosquet, Mariangela Cavarelli, Anne-Sophie Gallouët, Quentin Pascal, Thibaut Naninck, Nidhal Kahlaoui, Julien Lemaitre, Francis Relouzat, Giuseppe Ronzitti, Hendrik Jan Thibaut, Emanuele Montomoli, James M Wilson, Roger Le Grand, Luk H Vandenberghe

Journal: Mol Ther

PubMed ID: 35546782

Doi: 10.1016/j.ymthe.2022.05.007

Products & Services: Catalog Peptides

Overdominant and partially dominant mutations drive clonal adaptation in diploid Saccharomyces cerevisiae

Authors: Dimitra Aggeli, Daniel A Marad, Xianan Liu, Sean W Buskirk, Sasha F Levy, Gregory I Lang

Journal: Genetics

PubMed ID: 35435209

Doi: 10.1093/genetics/iyac061

Products & Services: Plasmid DNA Preparation

Scalable biological signal recording in mammalian cells using Cas12a base editors

Authors: Hannah R Kempton, Kasey S Love, Lucie Y Guo, Lei S Qi

Journal: Nat Chem Biol

PubMed ID: 35637351

Doi: 10.1038/s41589-022-01034-2

Products & Services: ELISA Kits

Convergent Alterations of a Protein Hub Produce Divergent Effects within a Binding Site

Authors: Ali Imran, Brandon S Moyer, Dan Kalina, Thomas M Duncan, Kelsey J Moody, Aaron J Wolfe, Michael S Cosgrove, Liviu Movileanu

Journal: ACS Chem Biol

PubMed ID: 35613319

Doi: 10.1021/acschembio.2c00273

Products & Services: Protein and Antibody Isolation

The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer

Authors: Almutasem Saleh, Yasunori Noguchi, Ricardo Aramayo, Marina E Ivanova, Kathryn M Stevens, Alex Montoya, S Sunidhi, Nicolas Lopez Carranza, Marcin J Skwark, Christian Speck

Journal: Nat Commun

PubMed ID: 35614055

Doi: 10.1038/s41467-022-30576-1

Products & Services: Mutant Libraries