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Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

Authors: Torleif Tollefsrud Gjølberg, Rahel Frick, Simone Mester, Stian Foss, Algirdas Grevys, Lene Støkken Høydahl, Øystein Kalsnes Jørstad, Tilman Schlothauer, Inger Sandlie, Morten C Moe, Jan Terje Andersen

Journal: Commun Biol

PubMed ID: 35982144

Doi: 10.1038/s42003-022-03787-x

Products & Services: Custom Vector Construction

Conversion of anterograde into retrograde trains is an intrinsic property of intraflagellar transport

Authors: Adrian Pascal Nievergelt, Ilia Zykov, Dennis Diener, Aditya Chhatre, Tim-Oliver Buchholz, Markus Delling, Stefan Diez, Florian Jug, Luděk Štěpánek, Gaia Pigino

Journal: Curr Biol

PubMed ID: 35926510

Doi: 10.1016/j.cub.2022.07.033

Products & Services: Codon Optimization

Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles

Authors: Ashwanth C Francis, Anna Cereseto, Parmit K Singh, Jiong Shi, Eric Poeschla, Alan N Engelman, Christopher Aiken, Gregory B Melikyan

Journal: PLoS Pathog

PubMed ID: 35951676

Doi: 10.1371/journal.ppat.1010754

Products & Services: Protein and Antibody Isolation

Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

Authors: Ryo Fujisawa, Cristian Polo Rivera, Karim P M Labib

Journal: Elife

PubMed ID: 35920641

Doi: 10.7554/eLife.76763

Products & Services: Gene Synthesis

Architecture and self-assembly of the jumbo bacteriophage nuclear shell

Authors: Thomas G Laughlin, Amar Deep, Amy M Prichard, Christian Seitz, Yajie Gu, Eray Enustun, Sergey Suslov, Kanika Khanna, Erica A Birkholz, Emily Armbruster, J Andrew McCammon, Rommie E Amaro, Joe Pogliano, Kevin D Corbett, Elizabeth Villa

Journal: Nature

PubMed ID: 35922510

Doi: 10.1038/s41586-022-05013-4

Products & Services: Plasmid DNA Preparation

Marburg Virus VP30 Is Required for Transcription Initiation at the Glycoprotein Gene

Authors: Megan R Edwards, Olivia A Vogel, Hiroyuki Mori, Robert A Davey, Christopher F Basler

Journal: MBio

PubMed ID: 35997284

Doi: 10.1128/mbio.02243-22

Products & Services: Protein and Antibody Isolation

Free-energy landscape of two-state protein acylphosphatase with large contact order revealed by force-dependent folding and unfolding dynamics

Authors: Xuening Ma, Hao Sun, Haiyan Hong, Zilong Guo, Huanhuan Su, Hu Chen

Journal: Phys Rev E

PubMed ID: 36109974

Doi: 10.1103/PhysRevE.106.024404

Products & Services: Plasmid DNA Preparation

CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphoma

Authors: Lihe Su, Lan Wu, Roy R Lobb, Paul D Rennert, Christine Ambrose

Journal: Oncoimmunology

PubMed ID: 35990518

Doi: 10.1080/2162402X.2022.2111904

Products & Services: Mammalian Expression

Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts

Authors: Haarin Chun, James H Kurasawa, Philip Olivares, Ekaterina S Marakasova, Svetlana A Shestopal, Gabriela U Hassink, Elena Karnaukhova, Mary Migliorini, Juliet O Obi, Ally K Smith, Patrick L Wintrode, Prasannavenkatesh Durai, Keunwan Park, Daniel Deredge, Dudley K Strickland, Andrey G Sarafanov

Journal: J Thromb Haemost

PubMed ID: 35810466

Doi: 10.1111/jth.15817

Products & Services: Gene Fragments

Efﬁcacy of glucose transporter inhibitors for the treatment of ERRα-overexpressed colorectal cancer

Authors: Miao Zhao, Cairong Xu, Hui Zhu

Journal: Acta Biochim Pol

PubMed ID: 36026615

Doi: 10.18388/abp.2020_5852

Products & Services: Custom Vector Construction