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Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses

Authors: Ruyu Wang, Guanglei Zhai, Guanghao Zhu, Mengge Wang, Xiaoyi Gong, Weidong Zhang, Guangbo Ge, Hongzhuan Chen, Lili Chen

Journal: Bioorg Chem

PubMed ID: 36395603

Doi: 10.1016/j.bioorg.2022.106264

Products & Services: Gene Synthesis

Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans : A target for antifungals

Authors: Erica J. Washington; Ye Zhou; Allen L. Hsu; Matthew Petrovich; Jennifer L. Tenor; Dena L. Toffaletti; Ziqiang Guan; John R. Perfect; Mario J. Borgnia; Alberto Bartesaghi; Richard G. Brennan

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 39083421

Doi: 10.1073/pnas.2314087121

A basal actinopterygian melanocortin receptor: molecular and functional characterization of an Mc2r ortholog from the Senegal bichir (Polypterus senegalus).

Authors: Ciaran A Shaughnessy , Mary F Jensen , Robert M Dores

Journal: Gen Comp Endocrinol

PubMed ID: 35973587

Doi: 10.1016/j.ygcen.2022.114105

Products & Services: Gene Synthesis

A genetic approach to identify amino acids in Gcn1 required for Gcn2 activation

Authors: Susanne Gottfried , Siaosi M B M J Koloamatangi , Clement Daube , Anja H Schiemann , Evelyn Sattlegger

Journal: PLoS ONE