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AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling

Authors: Renata Ferrarotto, Vasudha Mishra, Elad Herz, Adar Yaacov, Oz Solomon, Rami Rauch, Adi Mondshine, Maria Motin, Tal Leibovich-Rivkin, Matti Davis, Joel Kaye, Christopher R Weber, Le Shen, Alexander T Pearson, Ari J Rosenberg, Xiangying Chen, Alka Singh, Jon C Aster, Nishant Agrawal, Evgeny Izumchenko

Journal: Cell Death Dis

PubMed ID: 35931701

Doi: 10.1038/s41419-022-05133-9

Products & Services: Mammalian Expression

Oral glucagon-like peptide 1 analogue ameliorates glucose intolerance in db/db mice

Authors: Hanlin Zhang, Meng Dong, Shouli Yuan, Wanzhu Jin

Journal: Biotechnol Lett

PubMed ID: 36006576

Doi: 10.1007/s10529-022-03288-1

Products & Services: Peptide Synthesis

Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain

Authors: Jing-Yi Zhou, Rui-Rui Yang, Jie Chang, Jia Song, Zi-Sheng Fan, Ying-Hui Zhang, Cheng-Hao Lu, Hua-Liang Jiang, Ming-Yue Zheng, Su-Lin Zhang

Journal: Acta Pharmacol Sin

PubMed ID: 35918411

Doi: 10.1038/s41401-022-00936-0

Products & Services: Catalog Antibodies

A Localized Materials-Based Strategy to Non-Virally Deliver Chondroitinase ABC mRNA Improves Hindlimb Function in a Rat Spinal Cord Injury Model

Authors: Andrew S Khalil, Daniel Hellenbrand, Kaitlyn Reichl, Jennifer Umhoefer, Mallory Filipp, Joshua Choe, Amgad Hanna, William L Murphy

Journal: Adv Healthc Mater

PubMed ID: 35882512

Doi: 10.1002/adhm.202200206

Products & Services: Plasmid DNA Preparation

KIF20A promotes the development of fibrosarcoma via PI3K-Akt signaling pathway

Authors: Zheng Jin, Shuang Tao, Chao Zhang, Damo Xu, Zhenhua Zhu

Journal: Exp Cell Res

PubMed ID: 36037925

Doi: 10.1016/j.yexcr.2022.113322

Products & Services: Protein and Antibody Isolation

Pericentrin interacts with Kinesin-1 to drive centriole motility

Authors: Matthew R Hannaford, Rong Liu, Neil Billington, Zachary T Swider, Brian J Galletta, Carey J Fagerstrom, Christian Combs, James R Sellers, Nasser M Rusan

Journal: J Cell Biol

PubMed ID: 35929834

Doi: 10.1083/jcb.202112097

Products & Services: Catalog Peptides

Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA1, BA2 and BA3 following third mRNA vaccination

Authors: Lorenza Bellusci, Gabrielle Grubbs, Fatema Tuz Zahra, David Forgacs, Hana Golding, Ted M Ross, Surender Khurana

Journal: Nat Commun

PubMed ID: 35941152

Doi: 10.1038/s41467-022-32298-w

Products & Services: PCR Cloning and Subcloning

Third Early "Booster" Dose Strategy in France of bnt162b2 SARS-CoV-2 Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients Enhances Neutralizing Antibody Responses

Authors: Abdelhakim Ahmed-Belkacem, Rabah Redjoul, Rozenn Brillet, Nazim Ahnou, Mathieu Leclerc, Dennis Salomón López-Molina, Alexandre Soulier, Aurélie Gourgeon, Christophe Rodriguez, Sébastien Maury, Jean-Michel Pawlotsky, Slim Fourati

Journal: Viruses

PubMed ID: 36146735

Doi: 10.3390/v14091928

Products & Services: Monoclonal Antibody Services

The effect of substance P and its common in vivo-formed metabolites on MRGPRX2 and human mast cell activation

Authors: Lin Hsin, Nithya A Fernandopulle, Jie Ding, Chris Lumb, Nicholas Veldhuis, John A Karas, Susan E Northfield, Graham A Mackay

Journal: Pharmacol Res Perspect

PubMed ID: 35904495

Doi: 10.1002/prp2.990

Products & Services: Mammalian Expression

Expanding the antiviral potential of the mosquito lipid-transfer protein AEG12 against SARS-CoV-2 using hydrophobic antiviral ligands

Authors: Alexander C Y Foo, Bernard A P Lafont, Geoffrey A Mueller

Journal: FEBS Lett

PubMed ID: 35891619

Doi: 10.1002/1873-3468.14456

Products & Services: Catalog Peptides