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Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer

Authors: Carmela Martini, Jessica M Logan, Alexandra Sorvina, Colin Gordon, Andrew R Beck, Ben S-Y Ung, Maria C Caruso, Courtney Moore, Ashleigh Hocking, Ian R D Johnson, Ka Lok Li, Litsa Karageorgos, Ashley M Hopkins, Adrian J Esterman, Chelsea Huzzell, Robert D Brooks, Joanna Lazniewska, Shane M Hickey, Christie Bader, Emma Parkinson-Lawrence, Roberto Weigert, Michael J Sorich, Prerna Tewari, Cara Martin, Sharon O'Toole, Mark Bates, Mark Ward, Bashir Mohammed, Helen Keegan, William Watson, Sophie Prendergast, Sheena Heffernan, Sarah NiMhaolcatha, Roisin O'Connor, Victoria Malone, Marguerite Carter, Katie Ryan, Nathan Brady, Andres Clarke, Filip Sokol, Sarita Prabhakaran, Jürgen Stahl, Sonja Klebe, Hemamali Samaratunga, Brett Delahunt, Stavros Selemidis, Kim L Moretti, Lisa M Butler, John J O'Leary, Douglas A Brooks

Journal: Pathology

PubMed ID: 36089417

Doi: 10.1016/j.pathol.2022.08.001

Products & Services: Monoclonal Antibody Services

Disruption of nuclear envelope integrity as a possible initiating event in tauopathies

Authors: Marine Prissette, Wen Fury, Matthew Koss, Claudia Racioppi, Daria Fedorova, Ella Dragileva, Georgia Clarke, Taylor Pohl, John Dugan, Diana Ahrens, Joyce Chiu, Charleen Hunt, Chia-Jen Siao, Tara Young, Arijit Bhowmick, Vitaliy Rogulin, Mathieu Desclaux, Eric Y Hayden, Michael Podgorski, Min Gao, Lynn E Macdonald, David Frendewey, George D Yancopoulos, Brian Zambrowicz

Journal: Cell Rep

PubMed ID: 36001963

Doi: 10.1016/j.celrep.2022.111249

Products & Services: Synthetic Guide RNA

A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA

Authors: Vincent V Pham, Michael Gao, Jennifer L Meagher, Janet L Smith, Victoria M D'Souza

Journal: Commun Biol

PubMed ID: 35970937

Doi: 10.1038/s42003-022-03734-w

Products & Services: Plasmid DNA Preparation

Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators

Authors: Tan Tan, Chuanfen Wu, Boye Liu, Bih-Fang Pan, David H Hawke, Zehao Su, Shuaishuai Liu, Wei Zhang, Ruoning Wang, Sue-Hwa Lin, Jian Kuang

Journal: Mol Biol Cell

PubMed ID: 35976701

Doi: 10.1091/mbc.E22-04-0118

Products & Services: Protein and Antibody Isolation

Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth

Authors: Rossella Delle Donne, Rosa Iannucci, Laura Rinaldi, Luca Roberto, Maria A Oliva, Emanuela Senatore, Domenica Borzacchiello, Luca Lignitto, Giorgio Giurato, Francesca Rizzo, Assunta Sellitto, Francesco Chiuso, Salvatore Castaldo, Giovanni Scala, Virginia Campani, Valeria Nele, Giuseppe De Rosa, Chiara D'Ambrosio, Corrado Garbi, Andrea Scaloni, Alessandro Weisz, Concetta Ambrosino, Antonella Arcella, Antonio Feliciello

Journal: Commun Biol

PubMed ID: 35918402

Doi: 10.1038/s42003-022-03639-8

Products & Services: Gene Synthesis

Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

Authors: Sobhika Agarwala, Keun-Young Kim, Sebastien Phan, Saeyeon Ju, Ye Eun Kong, Guillaume A Castillon, Eric A Bushong, Mark H Ellisman, Owen J Tamplin

Journal: Elife

PubMed ID: 35943143

Doi: 10.7554/eLife.64835

Products & Services: Custom Vector Construction

Genetically Engineered Pigs as Efficient Salivary Gland Bioreactors for Production of Therapeutically Valuable Human Nerve Growth Factor

Authors: Fang Zeng, Sha Liao, Zhe Kuang, Qingchun Zhu, Hengxi Wei, Junsong Shi, Enqin Zheng, Zheng Xu, Sixiu Huang, Linjun Hong, Ting Gu, Jie Yang, Huaqiang Yang, Gengyuan Cai, Stefan Moisyadi, Johann Urschitz, Zicong Li, Zhenfang Wu

Journal: Cells

PubMed ID: 35954224

Doi: 10.3390/cells11152378

Products & Services: Plasmid DNA Preparation

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer

Authors: Wuqiang Zhan, Xiaolong Tian, Xiang Zhang, Shenghui Xing, Wenping Song, Qianying Liu, Aihua Hao, Yuxia Hu, Meng Zhang, Tianlei Ying, Zhenguo Chen, Fei Lan, Lei Sun

Journal: J Virol

PubMed ID: 35924918

Doi: 10.1128/jvi.00480-22

Products & Services: PCR Cloning and Subcloning

Screening of six cation exchange resins for high binding capacity, monomer purity and step yield: A case study

Authors: Wenwen Lu, Zhenzhen Zhang, Shengwei Zhang, Ting Zhang, Yan Wan, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 35970491

Doi: 10.1016/j.pep.2022.106155

Products & Services: Protein Electrophoresis and Western

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

Authors: Mohanraj Gopalswamy, Tobias Kroeger, David Bickel, Benedikt Frieg, Shahina Akter, Stephan Schott-Verdugo, Aldino Viegas, Thomas Pauly, Manuela Mayer, Julia Przibilla, Jens Reiners, Luitgard Nagel-Steger, Sander H J Smits, Georg Groth, Manuel Etzkorn, Holger Gohlke

Journal: Sci Rep

PubMed ID: 35986043

Doi: 10.1038/s41598-022-17913-6

Products & Services: Protein and Antibody Isolation